ID C9LRL0_SELS3 Unreviewed; 444 AA.
AC C9LRL0;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Glycine hydroxymethyltransferase {ECO:0000313|EMBL:EEX78476.1};
DE EC=2.1.2.1 {ECO:0000313|EMBL:EEX78476.1};
GN Name=glyA {ECO:0000313|EMBL:EEX78476.1};
GN OrderedLocusNames=Selsp_1925 {ECO:0000313|EMBL:AEC00878.1};
GN ORFNames=SELSPUOL_00076 {ECO:0000313|EMBL:EEX78476.1};
OS Selenomonas sputigena (strain ATCC 35185 / DSM 20758 / VPI D19B-28).
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Selenomonas.
OX NCBI_TaxID=546271 {ECO:0000313|EMBL:EEX78476.1, ECO:0000313|Proteomes:UP000003505};
RN [1] {ECO:0000313|EMBL:EEX78476.1, ECO:0000313|Proteomes:UP000003505}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35185 {ECO:0000313|EMBL:EEX78476.1}, and ATCC 35185 / DSM
RC 20758 / VPI D19B-28 {ECO:0000313|Proteomes:UP000003505};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEC00878.1, ECO:0000313|Proteomes:UP000011124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35185 {ECO:0000313|EMBL:AEC00878.1}, and ATCC 35185 / DSM
RC 20758 / VPI D19B-28 {ECO:0000313|Proteomes:UP000011124};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Peters L., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G.,
RA Teshima H., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Gronow S.,
RA Wellnitz S., Schneider S., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Selenomonas sputigena DSM 20758.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the SHMT family.
CC {ECO:0000256|ARBA:ARBA00006376}.
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DR EMBL; CP002637; AEC00878.1; -; Genomic_DNA.
DR EMBL; ACKP02000002; EEX78476.1; -; Genomic_DNA.
DR RefSeq; WP_006190648.1; NZ_GG698596.1.
DR AlphaFoldDB; C9LRL0; -.
DR STRING; 546271.Selsp_1925; -.
DR KEGG; ssg:Selsp_1925; -.
DR eggNOG; COG0112; Bacteria.
DR HOGENOM; CLU_022477_2_1_9; -.
DR OrthoDB; 9803846at2; -.
DR Proteomes; UP000003505; Unassembled WGS sequence.
DR Proteomes; UP000011124; Chromosome.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:InterPro.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF28; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR Pfam; PF00464; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:EEX78476.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011124};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEX78476.1}.
FT DOMAIN 10..368
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
SQ SEQUENCE 444 AA; 48978 MW; 8287EDCBE9651C49 CRC64;
MKKELLLSKL QAFDPEIFAL LQDEIQRQRY MLSLVPNNNA MSPFAHYLEG SLLANSAFDA
QNPNANSTNL EEIAIKRAKK LFGSEHAIVR LGNIGAASRV VCLALLQPNS RVLSFNLRKA
EHCSGLSFTF KNFGIDAKKQ VLDWDEVEQR ADETKPHLII FSPVSYPRNA NYRRLSEIAR
KVGAYLWVDI GQSVGLVAAG LLPSPVPFAD VVTFPTNDSL HGPDGAIVLS TKEIGQKLDE
TVINTGHTSL HINHMAALAA ALLEAGTETF RQYGKQVLAN SKELEHTLEM SGIPLLCDGT
DTHLVLPLLP AELQEIDITE YMGKAGFQVK ADRVPTMQKD QYLPALRLSS LTPTIRSLKE
KEIADIGALL STALKKKLPD TDLESIRNRI ATLVMNKPIF SEEWLTSSKM GTHAVYNSAN
SSAAHEAAST EKKNIIKNFF HLKN
//
