ID C9RA25_AMMDK Unreviewed; 382 AA.
AC C9RA25;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:ACX53154.1};
GN OrderedLocusNames=Adeg_2076 {ECO:0000313|EMBL:ACX53154.1};
OS Ammonifex degensii (strain DSM 10501 / KC4).
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Ammonifex.
OX NCBI_TaxID=429009 {ECO:0000313|EMBL:ACX53154.1, ECO:0000313|Proteomes:UP000002620};
RN [1] {ECO:0000313|EMBL:ACX53154.1, ECO:0000313|Proteomes:UP000002620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10501 / KC4 {ECO:0000313|Proteomes:UP000002620};
RG US DOE Joint Genome Institute;
RA Kerfeld C., Goodner B., Huber H., Stetter K., Lucas S., Copeland A.,
RA Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L.,
RA Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Ovchinnikova G., Richardson P.;
RT "Complete sequence of chromosome of Ammonifex degensii KC4.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP001785; ACX53154.1; -; Genomic_DNA.
DR RefSeq; WP_015740030.1; NC_013385.1.
DR AlphaFoldDB; C9RA25; -.
DR STRING; 429009.Adeg_2076; -.
DR KEGG; adg:Adeg_2076; -.
DR eggNOG; COG0535; Bacteria.
DR HOGENOM; CLU_009273_4_0_9; -.
DR OrthoDB; 9808591at2; -.
DR Proteomes; UP000002620; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd21123; SPASM_MftC-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR034479; AhbC-like.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR017200; PqqE-like.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR PIRSF; PIRSF037420; PQQ_syn_pqqE; 1.
DR SFLD; SFLDF00543; alternative_heme_biosynthesis; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002620};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 25..242
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 382 AA; 43344 MW; 87E3FC2C20C149ED CRC64;
MLSVSKMVSG QEELGDKLRY VGKVETARPV VVWNSTRACN LRCRHCYASA TPGPAPGEMT
TEEARRFIQG LAKTEVPVLL FSGGEPLLRP DFFELVNYAR SLGLRPVIST NGTLIDRAVA
RKLKELGVGY VGISLDGLKE FNDRMRGVPG AFEAALEGIR ACREVGQRVG LRFTITRDNY
REIPKIFDLV EEEKIDRVCF YHLVSVGRGK NLQQEDLEPE AKRQVLDLII ERALYFHRKG
IKKEILTVDN HADGVYLYLQ LQGEKPDWAE KVYVWLKANG GNRSGIGIGA VDWWGNVYPD
QFTHNHKLGN VKEKSFGTIW FEDPPELLVM LRDRRRYLKG RCARCRWLDL CNGNFRARAE
AVYGDFWAPD PGCYLTDTEI GL
//
