ID C9RKG0_FIBSS Unreviewed; 803 AA.
AC C9RKG0;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=FSU_0687 {ECO:0000313|EMBL:ADL24804.1};
OS Fibrobacter succinogenes (strain ATCC 19169 / S85).
OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC Fibrobacter.
OX NCBI_TaxID=59374 {ECO:0000313|EMBL:ADL24804.1, ECO:0000313|Proteomes:UP000000517};
RN [1] {ECO:0000313|Proteomes:UP000000517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19169 / S85 {ECO:0000313|Proteomes:UP000000517};
RA Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B.,
RA Russell J.B., Cann I.K.O., Mackie R.I., White B.A.;
RT "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP002158; ADL24804.1; -; Genomic_DNA.
DR RefSeq; WP_012820118.1; NC_017448.1.
DR AlphaFoldDB; C9RKG0; -.
DR STRING; 59374.FSU_0687; -.
DR GeneID; 34754635; -.
DR KEGG; fsc:FSU_0687; -.
DR PATRIC; fig|59374.8.peg.661; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_5_0; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000000517; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 19..324
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 325..632
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 40..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 803 AA; 92269 MW; AB4639B359B9EA42 CRC64;
MEKSPKSENI ENSLEWERSR LDKEQLEAVE TTEGYVRVVA GAGSGKTRTL THRYLYLVKE
MGISPANILC VTFTNKAAAE MKKRIRSILG GDDSGYISTF HGFCVQFLRE EIHVLNYPKE
FMILDEDDQK SLLRKAYADL GFSLKDLKIS SVLDFVGGRK ANDIGYVSLF AEHLADEVGA
SAAENAPAVE NEKREHLVEL ADEAPDKWMA VYYRYLYEQK KNYALDFDDL ILVTLYILEN
FPEKLDKWRK RMMYVMVDEY QDIDGQQYCL ADLLSSYHKN LFVVGDPDQT IYGWRGADIN
RILEFDQFHK GTKTILLQNN YRSTPSILKV PDAVIKNNKY RIEKVLRPVR AGGKTPVFYH
AKNTREEAKW IVERIQNAVQ NSVKNGAGGV HYKDIAVLYR MHSQSRSVEE ALMSESIPYK
VYSGVGFYQR KEIKDIICYL RMLVYADDLS FIRTVNTPKR QFGPKKMAIL QAFADTRKVG
LYEALLEIVY EAGRLNDVAP DVTTQAELSS VGNDHRKIDF DCKEFLSRSN VVEYVKLIEK
YRSRYKDMRV SELLSKMLRE TKYEEMLRLD GDEDRLDNLA ELKQGILEFE NYYEEDASLD
EYLQNIVLFT NADEDSQEKD RVQLMTIHNA KGLEFPYVFV CGLNEGFFPV KRVQNKMQLE
EERRLAYVAF TRAENVLCLS DAEDGVAGES GSRYPSRFLL EMNMDELDVA RGFSDDLLLA
ARAFIAESDR NRDLMNDFDE DESLGAVKKA PTAEFAVGDR VVHKIFGIGT VSGVDKKNFC
YEITFDKFAT PRSIQFDFPL VRG
//
