ID C9RRQ8_FIBSS Unreviewed; 295 AA.
AC C9RRQ8;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=orotidine-5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00012321};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN Name=pyrF {ECO:0000313|EMBL:ADL26879.1};
GN OrderedLocusNames=FSU_2138 {ECO:0000313|EMBL:ADL26879.1};
OS Fibrobacter succinogenes (strain ATCC 19169 / S85).
OC Bacteria; Fibrobacterota; Fibrobacteria; Fibrobacterales; Fibrobacteraceae;
OC Fibrobacter.
OX NCBI_TaxID=59374 {ECO:0000313|EMBL:ADL26879.1, ECO:0000313|Proteomes:UP000000517};
RN [1] {ECO:0000313|Proteomes:UP000000517}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19169 / S85 {ECO:0000313|Proteomes:UP000000517};
RA Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B.,
RA Russell J.B., Cann I.K.O., Mackie R.I., White B.A.;
RT "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001419};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00008847}.
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DR EMBL; CP002158; ADL26879.1; -; Genomic_DNA.
DR RefSeq; WP_014546324.1; NC_017448.1.
DR AlphaFoldDB; C9RRQ8; -.
DR STRING; 59374.FSU_2138; -.
DR GeneID; 34756001; -.
DR KEGG; fsc:FSU_2138; -.
DR PATRIC; fig|59374.8.peg.2051; -.
DR eggNOG; COG0284; Bacteria.
DR HOGENOM; CLU_060704_1_0_0; -.
DR OrthoDB; 9808470at2; -.
DR UniPathway; UPA00070; UER00120.
DR Proteomes; UP000000517; Chromosome.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011995; OMPdecase_type-2.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR02127; pyrF_sub2; 1.
DR PANTHER; PTHR43375; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43375:SF1; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:ADL26879.1}.
FT DOMAIN 18..282
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 295 AA; 32153 MW; A76339C273235D82 CRC64;
MTCFYDRLEQ RIAKCGNPVC MGMDPVLKLI PLEGTPEDRI KRFYSDILEC CLKRNVQPAV
VKPNSAYYEC VSVQSMLVLQ QLIADYRSAG IPVILDAKRG DIGKSSAAYA NAAYDVYRAD
AVTVSPWMGA DSVGPFIRED SENGAYVLLR TSNKGAHDFQ DLPVTRSDDP RDVAEAFYSV
ADKIMEWDAD KGYLGAVVGA THPEELEKIT AYTVAHKHEI PFLIPGVSIP GVPGGQGGDA
KTVLKAIQNG GGKRKFHVLN SSSGLNFAWQ RNDTPANYAN DCVDALEKLA EACLI
//
