ID   C9SWC8_VERA1            Unreviewed;       834 AA.
AC   C9SWC8;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=alpha-glucosidase {ECO:0000256|ARBA:ARBA00012741};
DE            EC=3.2.1.20 {ECO:0000256|ARBA:ARBA00012741};
GN   ORFNames=VDBG_09203 {ECO:0000313|EMBL:EEY23093.1};
OS   Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)
OS   (Verticillium wilt of alfalfa) (Verticillium albo-atrum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=526221 {ECO:0000313|Proteomes:UP000008698};
RN   [1] {ECO:0000313|Proteomes:UP000008698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VaMs.102 / ATCC MYA-4576 / FGSC 10136
RC   {ECO:0000313|Proteomes:UP000008698};
RX   PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA   Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA   Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA   Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA   Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA   Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA   Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT   "Comparative genomics yields insights into niche adaptation of plant
RT   vascular wilt pathogens.";
RL   PLoS Pathog. 7:E1002137-E1002137(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-
CC         glucose residues with release of alpha-D-glucose.; EC=3.2.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00001657};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC       {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
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DR   EMBL; DS985227; EEY23093.1; -; Genomic_DNA.
DR   RefSeq; XP_003000708.1; XM_003000662.1.
DR   AlphaFoldDB; C9SWC8; -.
DR   STRING; 526221.C9SWC8; -.
DR   GeneID; 9528420; -.
DR   KEGG; val:VDBG_09203; -.
DR   eggNOG; KOG1066; Eukaryota.
DR   HOGENOM; CLU_005043_1_0_1; -.
DR   OMA; FNTWHYG; -.
DR   OrthoDB; 5486960at2759; -.
DR   Proteomes; UP000008698; Unassembled WGS sequence.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd06595; GH31_u1; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR048395; Glyco_hydro_31_C.
DR   InterPro; IPR000322; Glyco_hydro_31_TIM.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR   PANTHER; PTHR22762:SF89; ALPHA-XYLOSIDASE; 1.
DR   Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR   Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|RuleBase:RU361185};
KW   Hydrolase {ECO:0000256|RuleBase:RU361185, ECO:0000313|EMBL:EEY23093.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008698}.
FT   DOMAIN          221..526
FT                   /note="Glycoside hydrolase family 31 TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF01055"
FT   DOMAIN          535..625
FT                   /note="Glycosyl hydrolase family 31 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21365"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   834 AA;  94214 MW;  BF04F2AF38706720 CRC64;
     MGGASILSSS QKQRPMVIDS SSSKHGMDKY KFPSDPVAHK ASTIAGSNYR FTVIKPSVLR
     YEWSPDGTFE DRASTFAINR KFDKPDYSVK ETEDQLEIVT PSLHLSYDKK RFSPNGFLVT
     FINKATLWGS EWRYGGEHDG GNLGGTARTL DGVNGRCDMG DGILSRSGFA NLDDSESMLF
     DGEGFVAPRK SGDRIDGYLF SYGQDYKSAM RDYHDISGKQ PLVPRWALGN WWSRYHAYSD
     KEYLDLMNKF EDQKIPLSTA VIDMDWHLVH EEQVTHTGWT GYTWNKSLFP DHVAFCKDLH
     ERHLKITLND HPHAGVHHFE DLYEKVAKAM GYDTSDNAPI LFTPTDPNFM HAFLNVLHRS
     LEEDGCDFWW IDWQQGPYSR IPGLDPLWLL NHFQYLDDSI QRNGSGAIIF SRYGGPGSHR
     YPVGFSGDSI STWESLAFQP EFTATASNVG YGWWSHDIGG HVAGSRDDEL ATRWTQYGVF
     SPIMRLHSSN SEWMGKEPWG YREEYAAILR HFMRLRHRLV PYIYTMNVNA AASDEPLVQP
     LYWSHPGRGI AYDLRNQYTF GSNLVVRPVT GRRDTRTNLA SEKVWVPPGR HVDIFNGYVY
     DGDREINMYR PLQSFPALAR EGAIIPLDKA LEPKNGCFNP AGYEVLVVVG QDGEFTIIED
     PKDDSAESSK STEATEERHI KIEWDQKLGH LKTTSKGKQW KFNFLSVRTI SPTLSVLVDG
     LETPDVIVTT QTHAASSHTP YSMTVELPKL PNADCTILVD LGADPQLGVI DRNNQIHAML
     QDAQIDYGTK DRIWSIVRSS EPASTKVGKL MTLNLEGNVL GPVLEILFAD SREA
//