ID C9XUG4_CROTZ Unreviewed; 320 AA.
AC C9XUG4;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=PTS system mannose-specific EIIAB component {ECO:0000256|ARBA:ARBA00021685};
DE EC=2.7.1.191 {ECO:0000256|ARBA:ARBA00011929};
DE AltName: Full=EIIAB-Man {ECO:0000256|ARBA:ARBA00032197};
DE AltName: Full=EIII-Man {ECO:0000256|ARBA:ARBA00030229};
GN Name=manX {ECO:0000313|EMBL:CBA31604.1};
GN OrderedLocusNames=Ctu_25000 {ECO:0000313|EMBL:CBA31604.1};
OS Cronobacter turicensis (strain DSM 18703 / CCUG 55852 / LMG 23827 / z3032).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Cronobacter.
OX NCBI_TaxID=693216 {ECO:0000313|EMBL:CBA31604.1, ECO:0000313|Proteomes:UP000002069};
RN [1] {ECO:0000313|Proteomes:UP000002069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18703 / CCUG 55852 / LMG 23827 / z3032
RC {ECO:0000313|Proteomes:UP000002069};
RX PubMed=21037008; DOI=10.1128/JB.01162-10;
RA Stephan R., Lehner A., Tischler P., Rattei T.;
RT "Complete genome sequence of Cronobacter turicensis LMG 23827, a food-borne
RT pathogen causing deaths in neonates.";
RL J. Bacteriol. 193:309-310(2011).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (sugar PTS), a major carbohydrate active transport system,
CC catalyzes the phosphorylation of incoming sugar substrates
CC concomitantly with their translocation across the cell membrane. The
CC enzyme II ManXYZ PTS system is involved in mannose transport.
CC {ECO:0000256|ARBA:ARBA00023757}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-
CC mannose 6-phosphate(in) + L-histidyl-[protein]; Xref=Rhea:RHEA:49232,
CC Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746, ChEBI:CHEBI:4208,
CC ChEBI:CHEBI:29979, ChEBI:CHEBI:58735, ChEBI:CHEBI:64837;
CC EC=2.7.1.191; Evidence={ECO:0000256|ARBA:ARBA00000514};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FN543093; CBA31604.1; -; Genomic_DNA.
DR AlphaFoldDB; C9XUG4; -.
DR KEGG; ctu:CTU_25000; -.
DR PATRIC; fig|693216.3.peg.2370; -.
DR HOGENOM; CLU_074797_0_0_6; -.
DR Proteomes; UP000002069; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00006; PTS_IIA_man; 1.
DR CDD; cd00001; PTS_IIB_man; 1.
DR Gene3D; 3.40.50.510; Phosphotransferase system, mannose-type IIA component; 1.
DR Gene3D; 3.40.35.10; Phosphotransferase system, sorbose subfamily IIB component; 1.
DR InterPro; IPR013789; PTS_EIIA_man.
DR InterPro; IPR004701; PTS_EIIA_man-typ.
DR InterPro; IPR036662; PTS_EIIA_man-typ_sf.
DR InterPro; IPR033887; PTS_IIA_man.
DR InterPro; IPR004720; PTS_IIB_sorbose-sp.
DR InterPro; IPR036667; PTS_IIB_sorbose-sp_sf.
DR InterPro; IPR018455; PTS_IIB_sorbose-sp_subgr.
DR NCBIfam; TIGR00824; EIIA-man; 1.
DR NCBIfam; TIGR00854; pts-sorbose; 1.
DR PANTHER; PTHR33799:SF1; PHOSPHOTRANSFERASE ENZYME IIA COMPONENT YADI-RELATED; 1.
DR PANTHER; PTHR33799; PTS PERMEASE-RELATED-RELATED; 1.
DR Pfam; PF03610; EIIA-man; 1.
DR Pfam; PF03830; PTSIIB_sorb; 1.
DR SUPFAM; SSF52728; PTS IIb component; 1.
DR SUPFAM; SSF53062; PTS system fructose IIA component-like; 1.
DR PROSITE; PS51096; PTS_EIIA_TYPE_4; 1.
DR PROSITE; PS51101; PTS_EIIB_TYPE_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CBA31604.1};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..126
FT /note="PTS EIIA type-4"
FT /evidence="ECO:0000259|PROSITE:PS51096"
FT DOMAIN 157..320
FT /note="PTS EIIB type-4"
FT /evidence="ECO:0000259|PROSITE:PS51101"
SQ SEQUENCE 320 AA; 34707 MW; B44EBB6B98EB696D CRC64;
MTIAIVIGTH GWAAEQLLKT AEMLLGEQEN VGWIDFVPGE NAETLIEKYN AQLEKLDTSK
GVVFLVDTWG GSPFNAASRI VVDKPNYEVV AGVNIPMLVE TLMARDDDPS FDELIAIAVE
TGREGVKALK AKPAVKAAPA APAPKAAAPA RPMGPNDYMV IGLARIDDRL IHGQVATRWT
KETNVSRIIV VSDEVAADNV RKTLLTQVAP PGVTAHVVDV AKMIRVYNNP KYAGERVMLL
FTNPTDVERV VEGGVKITSV NIGGMAYRQG KTQVNNAVSV DEKDIEAFKK LNARGIELEV
RKVSNDPRLK MMDLLSKAAK
//
