ID   C9ZMQ5_TRYB9            Unreviewed;      1275 AA.
AC   C9ZMQ5;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=IQ calmodulin-binding motif containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TbgDal_IV2590 {ECO:0000313|EMBL:CBH10558.1};
OS   Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH10558.1, ECO:0000313|Proteomes:UP000002316};
RN   [1] {ECO:0000313|Proteomes:UP000002316}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX   PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA   Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA   Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA   Barry J.D., Berriman M., Hertz-Fowler C.;
RT   "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT   chronic human african trypanosomiasis.";
RL   PLoS Negl. Trop. Dis. 4:E658-E658(2010).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; FN554967; CBH10558.1; -; Genomic_DNA.
DR   RefSeq; XP_011772847.1; XM_011774545.1.
DR   AlphaFoldDB; C9ZMQ5; -.
DR   GeneID; 23859681; -.
DR   KEGG; tbg:TbgDal_IV2590; -.
DR   OrthoDB; 129566at2759; -.
DR   Proteomes; UP000002316; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.190; -; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR   PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR   Pfam; PF00612; IQ; 2.
DR   SMART; SM00015; IQ; 5.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50096; IQ; 2.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          514..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          610..708
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..351
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..402
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..536
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        552..571
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        618..632
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        633..650
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..673
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        674..688
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1275 AA;  145513 MW;  3E925E382AD46A97 CRC64;
     MYGVTHPRQG NGGQKRKQKR PMDQAAATGP PVLLPSIQTD ARSVVEARNF DVMCGAEITT
     ATEQKYRNTG SMSSGVLGLD SSPETILNMN KEAMSLLNKG KMGACEDVLQ TALQLAESGV
     QNCRHAIMMS ADPTKQEELE AWQLVFATTL SNMGSVQRRV DQPQDALRYL QDACGVEEEV
     FGQPTCSTLL NLSTVMLNLG LFDDALNMAR NCASTAEGGD PLLHIIALHN YGIALRSHPS
     SEMKQSAAPV LMKALREAES NLGKDHPTTL IIRQRCGMAA AAPARTSTPG RSVRTPLQQR
     RSGEFGRQES SVSSGYSVKQ RGKQGSGSRT SRGNSTSGKR KSATGQKGST LPPVAQAPVD
     RLRVKQAIQR LDYGEIKKVV TTKMEECEST PSAVSSETDE EPVTPRPSAP PSHLPPPLPP
     IAVQEMSVST HNSQKCSDAS PFTPIFAVLN DNVMSLGSAS GDKSAFSNEM VWRWQPPVEL
     VEAAVPSLRE TQEEAPTSKV EATATPPAVP AVNEEEQVVP TIKNEERKEE MIQKQSRASS
     IRHLNKRGSM RRGKERRNEE RDSDVRNRST GSKKSSKLGC CGGYINLCES FSEGKPSFLH
     FGDREAAPHA AVSATEPVQH QFPGSVGPTN DPVSRREQRR RERLLLGFDD FDDIDIDEEE
     EEEEEEEEEE EEEKKEREKQ RDAKEGGEGT PGRFAVGDAE QKGEKKRMGI SKIIGTSPAV
     RRLQRIEKEK QEEEALRARW EREAAERAKK EIFERSLEKI VHRTRVRAAT TIQLVWIEWW
     ENIGKRRREL LNKRAADRER RERLRLALLD YESRLAQQQS KKAAPAVVEV GIPSVIKCVK
     RWMEKTACII YAVQKGLRRE ERDNNFFRSM IVKIQSAWRR IQAKRRSREI AITRDQRRAE
     TLEREPQEYA ALVIQKFVRC AFARQKRKQL RTERYRPAVI KVQRWFRQTY ARARMRGTDV
     VSCWRRKYSA RLIQRAWRGY LGRLNDAMNN LRFKLNETRR REREAATTIQ RVGRGHLLRC
     QVAKRAKDID RIYSTMRFLE LKATDGVEEQ QPLSTHATLP AYLPSDAEEV ARVAELEREK
     YHIGMFVEEV AKREREAWSD ALRFRPFEVQ RRRAGEDLLC QLEFNVYRRE RAATKIQREF
     RAWRRVRHDV LRDKTLLMKG RGDYMQNFFD NKVQKMLHRR RYEGGKELYG DHARPMREMK
     EEAQSELQEL CPLVRTHAHP TELRTREERC KAEEELLHDE ELVASEQVSD WLNFRRETLM
     NRFREEVSSA RGSCF
//