ID   C9ZQU3_TRYB9            Unreviewed;       300 AA.
AC   C9ZQU3;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=pyridoxal kinase {ECO:0000256|ARBA:ARBA00012104};
DE            EC=2.7.1.35 {ECO:0000256|ARBA:ARBA00012104};
GN   ORFNames=TbgDal_VI2510 {ECO:0000313|EMBL:CBH11773.1};
OS   Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH11773.1, ECO:0000313|Proteomes:UP000002316};
RN   [1] {ECO:0000313|Proteomes:UP000002316}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX   PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA   Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA   Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA   Barry J.D., Berriman M., Hertz-Fowler C.;
RT   "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT   chronic human african trypanosomiasis.";
RL   PLoS Negl. Trop. Dis. 4:E658-E658(2010).
CC   -!- SIMILARITY: Belongs to the pyridoxine kinase family.
CC       {ECO:0000256|ARBA:ARBA00008805}.
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DR   EMBL; FN554969; CBH11773.1; -; Genomic_DNA.
DR   RefSeq; XP_011774058.1; XM_011775756.1.
DR   AlphaFoldDB; C9ZQU3; -.
DR   GeneID; 23861896; -.
DR   KEGG; tbg:TbgDal_VI2510; -.
DR   VEuPathDB; TriTrypDB:Tbg972.6.2510; -.
DR   OrthoDB; 5472295at2759; -.
DR   Proteomes; UP000002316; Chromosome 6.
DR   GO; GO:0008478; F:pyridoxal kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009443; P:pyridoxal 5'-phosphate salvage; IEA:InterPro.
DR   CDD; cd01173; pyridoxal_pyridoxamine_kinase; 1.
DR   Gene3D; 3.40.1190.20; -; 1.
DR   InterPro; IPR013749; PM/HMP-P_kinase-1.
DR   InterPro; IPR004625; PyrdxlKinase.
DR   InterPro; IPR029056; Ribokinase-like.
DR   NCBIfam; TIGR00687; pyridox_kin; 1.
DR   PANTHER; PTHR10534; PYRIDOXAL KINASE; 1.
DR   PANTHER; PTHR10534:SF2; PYRIDOXAL KINASE; 1.
DR   Pfam; PF08543; Phos_pyr_kin; 1.
DR   SUPFAM; SSF53613; Ribokinase-like; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:CBH11773.1};
KW   Transferase {ECO:0000313|EMBL:CBH11773.1}.
FT   DOMAIN          99..262
FT                   /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT                   /evidence="ECO:0000259|Pfam:PF08543"
SQ   SEQUENCE   300 AA;  33346 MW;  7A68D6D41D7EB40B CRC64;
     MSEKTVLSIQ SFVTHGYVGN KAATFPLQLH GFDVDGINTV CLSNHSGYPV IRGHRMSLQE
     YDELMEGVRA NNFLSNYRYI LTGYINNVDI IGRIRDTLKE VRELREKEDK KLTFICDPVM
     GDDGIMYCKK EVLDAYRELV PLADIVTPNY FEASLLSGVT VNDLSSAILA ADWFHNCGVA
     HVIIKSFREQ EKPTHLRFLY SVKEGSEAAV RRFSGVVPYH EGRYTGTGDV FAACLLAFSH
     SHPMDVAIGK SMAVLQELII ATRKEGGDGK SSLKSRELRV VASPQVVLQP STVVDVKPIS
//