ID   C9ZVH7_TRYB9            Unreviewed;       345 AA.
AC   C9ZVH7;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE            EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
GN   ORFNames=TbgDal_VIII3620 {ECO:0000313|EMBL:CBH13415.1};
OS   Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH13415.1, ECO:0000313|Proteomes:UP000002316};
RN   [1] {ECO:0000313|Proteomes:UP000002316}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX   PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA   Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA   Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA   Barry J.D., Berriman M., Hertz-Fowler C.;
RT   "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT   chronic human african trypanosomiasis.";
RL   PLoS Negl. Trop. Dis. 4:E658-E658(2010).
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004992}.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|ARBA:ARBA00009776}.
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DR   EMBL; FN554971; CBH13415.1; -; Genomic_DNA.
DR   RefSeq; XP_011775692.1; XM_011777390.1.
DR   AlphaFoldDB; C9ZVH7; -.
DR   GeneID; 23863550; -.
DR   KEGG; tbg:TbgDal_VIII3620; -.
DR   VEuPathDB; TriTrypDB:Tbg972.8.3620; -.
DR   OrthoDB; 159727at2759; -.
DR   Proteomes; UP000002316; Chromosome 8.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01672; TMPK; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR   PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:CBH13415.1};
KW   Transferase {ECO:0000313|EMBL:CBH13415.1}.
FT   DOMAIN          133..319
FT                   /note="Thymidylate kinase-like"
FT                   /evidence="ECO:0000259|Pfam:PF02223"
SQ   SEQUENCE   345 AA;  39573 MW;  465AA7259BDE29D2 CRC64;
     MVAMNRKIVV FTDVEDKQVL EVIREVAGDA ETIQLEKSFA YEFMWRGKHT PYRVGTPMCF
     ITEKTVEDAD VVFAVYSKRV PVLSLTTGGE TTNLLQTISS LGIECKQNTS ETWADAVRAF
     LPNNDSEGAV IVFEGGDGAG KATQTEYMRK RLDKEGKAHA SLDFPSDKHR YGKLIRKVLS
     GERGALHDLD PKLFSLLFSL NRFDTLPELR YWLTHGKKIL LDRYYTSNFG HQASKLEESE
     RSDFIRHLEQ LELEWLKLPP PDVALYLDLP PAAALVAMQR DEKRESLDIH ETAGLSYKEN
     VRQTYVWCCQ NQRNWVQIEC CNDEGERYSR EKVHEMIYNA VAKHI
//