ID C9ZWU8_TRYB9 Unreviewed; 4942 AA.
AC C9ZWU8;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=TbgDal_VIII8310 {ECO:0000313|EMBL:CBH13887.1};
OS Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH13887.1, ECO:0000313|Proteomes:UP000002316};
RN [1] {ECO:0000313|Proteomes:UP000002316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA Barry J.D., Berriman M., Hertz-Fowler C.;
RT "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT chronic human african trypanosomiasis.";
RL PLoS Negl. Trop. Dis. 4:E658-E658(2010).
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DR EMBL; FN554971; CBH13887.1; -; Genomic_DNA.
DR RefSeq; XP_011776163.1; XM_011777861.1.
DR GeneID; 23864075; -.
DR KEGG; tbg:TbgDal_VIII8310; -.
DR VEuPathDB; TriTrypDB:Tbg972.8.8310; -.
DR OrthoDB; 161058at2759; -.
DR Proteomes; UP000002316; Chromosome 8.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR022099; DUF3638.
DR InterPro; IPR022105; DUF3645.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001876; Znf_RanBP2.
DR PANTHER; PTHR13367:SF35; RANBP2-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13367; UBIQUITIN THIOESTERASE; 1.
DR Pfam; PF12340; DUF3638; 1.
DR Pfam; PF12359; DUF3645; 1.
DR Pfam; PF13905; Thioredoxin_8; 1.
DR SMART; SM00547; ZnF_RBZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 4794..4823
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 2151..2188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2249..2281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4332..4356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4825..4845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2160..2179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2263..2280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4942 AA; 550465 MW; 554C769652FC77EF CRC64;
MRIEVKFARR TIVICLDDGP PPPLLRDLKQ ELYTQTGVQP AMQKLLGKPK LNNPANDSAS
LDSLGVGDIT KLMLVGSTAK DIVAANSAST AEDRRQEEVH GQMLHNVVRN TWLTCSFSGF
MADPYVGGKG PDFEHGTVEV ALLLLDVAVT RINTLGVNST ASNGAGDGSA GGPVGLQLLQ
TIGTEGQSAI SHPLLRHLNA LERQAIQRAH GVLRRCFHLT VMAKSAVNPP EVVKVVAKVV
SIVNGLSVGE WVMLPGGWTG MKSHTVIYLL IQRESAEEFN VVVVNRAADG SEYHPSWQTR
EKIVACPFLR FDHVAGARLL DRAFWLLLLS LWMRSNVPGP RSEFVRAEVF YDVLIPWLVE
RPPTRSNRQS STVSSGSLRS ATEMILRSPS NEGVDAAEAE GSGSQTTLPS AVQSYGATVA
RNCSGSIKGA VTSLLYLLEQ YGMKERAVQK SVKYALKYEF MMRAAEDLAA LADRFLKSAG
NWEGSDTGER QGLTTDKNFE CSRVERALNE LRSAGVGHTV SPISTKELFR TAHEKNIIFT
NDKNIILSQE HFSNKPLLVY CGGLQDPASA RFSTLLAEAV DQFRLSSPQV ELLFLSCDDT
KERYERHIAM FSFARAAYPC DVLVRKLYVT EVPKLLLFGP DGRLLHRRGV DALRADPSAT
LFPHGGLWNG AMPLTATDVA ILKSGAAVLA HHTRKRLAIT NSAVSERDGF IPVGEARRVL
RILSAVCTMV ELLPKEPNTA EGFLIQNTTK NDVHNNMIEG VATPQTQKDA ALVGQLFTLS
DIVEGNNSGG GDSSDCGGSC GRHECGVPME AVAFLNGSLL PATSTEAYKG QPLRTAVPEV
QSLTDLRPVT SWAQLHFTLK RAEAIIDALW LRARHSGTTS RVAIQMHIIE VISWLFLFII
PLPLPRGMDV RSVPEEERST VAEFYTVDAF PSAPTGDGSG ANGGRATDVQ GGLQESIYSL
MLSFTNAWQA VEVPTRAFDA ERGITAMEML VVYDAVARHT ANSASSVNSR LLASMLNCDG
GYYLSTSMGG QSLSFAQVSA SMELVRPQML IRRSALLRYI TEQQRRCAHE LFDLPMTDKL
EVRKNSVTVG FLRKLLDNCG YRLAETSGPS MFTAAGGSGG SEMEQLMQWF CSARSPLARD
HPEFGQLRDM VLLTKFLVTM EMRDAQLLRR RRQPDGDGGG RGATTWRLTF DADTPGLQMS
AGWRTKPMPP HWECMLVRGR DSDIADIVVT GFGGRELLYG EGLVLHSPID VGVMLGIESA
TEDDVLHAVA SKLPTFGGAM SAEESEVLLS CLTAPYLRLP LVLNFFASQS HHTYLFNAAV
QSLFRAALFE PGAFTTQQQQ SQLEPELVPM RLNRRQREEI EQRRLIGDLS AVNYEACLGT
PYGLLLNELQ HSPDAVLVPL HRILVGIEDI GPSSVYSANA SYVLFIVGVV CDVLAFCNLA
RELRDRELSG DGAAPGAVRD VLTSFVTTVL QFLVEIVRPM LLLWCTEGEE NDDTPTQCVV
HSYMASIHRA AWKYMVPTTS SNSPLSPTAL SSSNHLTSLL QSCCFVRARH SFGLGMQRTQ
VAMQEGDKLL TPREQLLRFL QAQGLDTADI SHDALEESQR LMLSGGRRRA VFVQIRSAYH
RDTVRVPNLY RSDARNTTEC KQLKLPPADV PENVIFGYLL EDHKDVLHFF SSIGAEQMSV
VFKLIVHTVL RDHTQGRGSR RMEEKKVRSN NCENAVGTEG NAEVSGGIAP TPTFPRHGTK
NEVVPQPVNE DHAELSAVSV VRGGDGHLGE PWKQTSPGVY RGPVSTGLVF HAHTCELFWR
NDELKPVPDS MSHFSDFKTI IGNDVLQCGL VSRSRNYHWV HIVGTPFDVV EWTPHDPLDQ
GVGAPLVLSG ELPKEPVTSA SFDGLMFNRP VDVYDEVPWL NRSERWAVDL LRAVLRYKYS
ANDMKYFPVA QAESPSAPLH QNNDGKEVRK GKGDGVRVMR FIMNDGPQYT DEDNRATWKE
IVAYRLPSPH LHVFNLVPHA RRVYRSLVFT SNQRWCLHSL PPITGPRPHD QLHLLAFQAG
ELDRRVQCEG SIEIHRYNSE LGMREMYVPA QLLQGVLPSV LLEVFLFWQD EEDNIRGYST
ADAQDYWFNY TLFVRLRSGK GVGAKGGILH NFRGGEWECV VTRRNNTQKY CANARKRPRS
RSTAASEVDG KHQKQLSPQW ENEEEAGTAA VEQHITDAQV SLMHSSLTFL TATACRTLLQ
RTKGDIHSAI SYALDPANQD DVMLLVSTEQ RKESESEGDE EETEQPCISK ERRHRGHSGN
NAGEELTLLN LTQSAKLFPL LHLLTRLEDC SHILLWGRVN SKDGSSRRCQ RGREDRRRCE
ENEEEGIDKC SVADVVLIEL PRLCITFYPH VDTATGSLRL HLADHPGWYI AEATDYISGV
QNFLPQLQEP FQQYVTLCNS TAGFALMVPN HDFTPMVVSG DPFNKLLLFD RSSLRWKERV
ASTFYLYTVH PCRSFLVPPS LAASLYYAVL QCATGHYAAA MRTLESCYTD STFTTEECFM
FTLMGRTLDD QHPDAHAVRL KLAHAVLYGP QKPQWPLHTE VAAYLQKKRH VSRACQLTRE
ELIDLMRRCN RSLPIVHAQL QLWAALEKEE EKLRLSNDTD ADTNVVPSPE TVVRLDTPLM
HRCGQPWERL LLYQWTHISS QRPRRITYKV LDEKALEDEE LVKFIWKDTL LSDEESGGNS
RLGFYFLYSL KQGGTAQPKL AGEDVRVTLC QLLTRWFHLR HSRWGREEQQ DGEAESRPSW
CGAVLQLMDI HPEAGWPAPP NSRHLLHRMN NGVSVVETRE VDEAESVVAL MDRPSPELVE
FYRKVEQVAC NLHGNSQVVQ QRRGDLLLSI AVTSARRVAH VHMRDHLQPR IVPSNTAMEC
LQVSFGSLLS AVPNVSRDDG VGKDAEEEHD KLMSAGNPWY QRLTALFGAP LSDMPCSAHL
ICTEQLTHED DPGDGRCGDC LPQLPFDLRK LPRCNAPLAK NMLDRLEADV GNFAMKQRQC
LSRTLTAFSQ ERLYAILRSR STIFATRQVY AEVTCELQRC IDELSALAAS DEALVHELTA
SILHSANDVC RSDCADEDAP GDEEDLLRAC DYQLQRIKGD QCPVPLEWLL CSLLSTEMDA
DLQAVNPFHG GTKLLQAQLL LLTVLTNRCH IAQQAKQAVR QVMLFLELCA LLRGMDDECK
YEASATRSFP VSHCSDDMGV MECHDASISW LQELLQLFSI GVDVDMLFKG EGQSTDGNLQ
LNKGSNTSSH NGLCCRCLPE DLLQVLESRL QHLSNEVIEA LTVRRYCTDL SCDGCGDSST
VVTLDPRYLM FEFIHNILLR ARQVEMVRWF VQNINAGVSR VQQMIMGQGK TTVVGPLLAL
ILADGQQLVT QVMPTALLEQ TSVILRRCFS VVIPKQIYTL KFDRSFDDSD SSQVNLLKQK
LTAATRKRGI LISAPECVKS VFLKMIEQLH LVESVMTEYI DAEDGKVAAC DTADERVAVR
KQELMHRTRQ RSSMADAIVP ILQLWQRGVL IMDEVDVLLH PLRSELNFPI GLKHPIELSG
PRWVLPMHLL DAIFFYQRRR TTTADGDAHG AFGDGHVKAT AIRLEGHPTG VGEDVQNEIL
GRICDVIAMG YETRALQREP HLVLLDSLYY NDQLLPALLP WAQLWLYRHF QLEKHACLLG
HATGLAASLG WRQFLEITTL FLKLGERPSR DSSIACVINS TFSPLGIQLL CLSHDWLHRI
MPHVLSKIDR VGFGLLQERE LALLSSEARD RMPLSRRTMA VPFVAKDVPS LSSEFAHPDV
VIGLTVLAYR YEGMRFADMR DLLLQLKQDF VRQSGPEDHR PAAKLYAQWL RLSLSCSAET
EPTSHGGGIL PRVVPSAITT MGTTCVEATN DRSGIPLSQL QVTDEVALHA LYLRLRRLPD
VIHYYLSSHI FPRTMNFQAL KISACGHELG SSMLFTRRIG FSGTPSNLLP LDLGDCFYEP
GSDGRVLSVL TNPQVVTVLP LQSDWTPLRL LDQIASSRSQ PFHALIDAGA LITNMDNETV
ARYLLSRLSA DLFDGVVFLD AKDRQMILQR SNGLLVPVAQ SGIALNRRFT FFDQVHTTGT
DIKQAATATA VLTLGKDLVF RDYAQGAYRM RGIGRGQRLC LFVIPEVLTR LNNSLGSVQT
GDLLLDIPAW LLLNSVRMEG LQFIKLTTQE IANVWRKKAL KYLVTDAIHA DAHPDAHTEA
GRCYRFDSRT RNLRLQEFSS SDSGACGGVS LPDGPLLRSS IREFREPVDF PVDSTVDTAV
PFLQRLKQQM NERPQELIRA EAGVPSDGCD PQRVLTELME RLELSLTLRA DGANVAVQDM
VGHLMNFDSE VVHEQEAEEE QEQEAEQEEQ RVSVASRDDE FQIPWRVQTL QAYGNLTNEE
LGNVGSKLVV KGGCFYSMQR FRLRPEQPAI MVDWKVQLSD NYFREEWHGV GERRLKNAFL
FLEWLPSDTA QSDVSTGAGG CVSGGSTLVP LQRVHCGLVT LAEGESLRWM MHHPSRHSGS
VRMALRMVSN GCYMDASAAF AEVFPYLTAQ QEGNRWELLN VPPSAPHMNS QQRCVGVLET
PSAERDGAAL LYRFFNNDMF FSVEELAVLG VMLKDVTHVD RLRFFTDCLR ARRRHRNHWD
DTPVAVLFVP PGQQMNARLL AILSIMQVRF EELQSRLCNV PPPPQLVDQL QSFHTRLNRL
HLEHVVDHHH HRERVQPRDT ENVLSVSAIA RVLFDVFSGI LKPYNLNDVL QALQYFVHRK
GSTVVLTEKL HNTTVDAAAA ESPFVRCVTE AFPVLNLEFL DRCLVALCAH NPAVEGPWHC
SACTLLNDPT VKRCLACNTA RATDTAGATG GISSDDPHGN ESHGGEAEES WACQQCTFIN
ESRRSPLCAV CLGPNPNPLP QSQPVHSSGD FMGADAGNVR GCPEGYWACL VEQGGCSKFN
PNTVFYCQVC DKARPGLATL RF
//
