ID CCD41_ARATH Reviewed; 308 AA.
AC Q8LGA1; Q9FKP7; Q9XFR7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 27-MAR-2024, entry version 135.
DE RecName: Full=Cyclin-D4-1;
DE AltName: Full=G1/S-specific cyclin-D4-1;
DE Short=CycD4;1;
GN Name=CYCD4-1; Synonyms=CYCD4.1; OrderedLocusNames=At5g65420;
GN ORFNames=MNA5.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP INDUCTION, AND INTERACTION WITH CDKA-1.
RX PubMed=10420643; DOI=10.1007/s004250050582;
RA de Veylder L., de Almeida Engler J., Burssens S., Manevski A., Lescure B.,
RA van Montagu M., Engler G., Inze D.;
RT "A new D-type cyclin of Arabidopsis thaliana expressed during lateral root
RT primordia formation.";
RL Planta 208:453-462(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH KRP4/ICK7; KRP5/ICK3; KRP6/ICK4 AND KRP7/ICK5.
RX PubMed=11449057; DOI=10.1105/tpc.010087;
RA de Veylder L., Beeckman T., Beemster G.T.S., Krols L., Terras F.,
RA Landrieu I., van der Schueren E., Maes S., Naudts M., Inze D.;
RT "Functional analysis of cyclin-dependent kinase inhibitors of
RT Arabidopsis.";
RL Plant Cell 13:1653-1667(2001).
RN [6]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INTERACTION WITH CDKA-1 AND
RP CDKB2-1.
RX PubMed=12857813; DOI=10.1104/pp.103.020644;
RA Kono A., Umeda-Hara C., Lee J., Ito M., Uchimiya H., Umeda M.;
RT "Arabidopsis D-type cyclin CYCD4;1 is a novel cyclin partner of B2-type
RT cyclin-dependent kinase.";
RL Plant Physiol. 132:1315-1321(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
RN [8]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16227434; DOI=10.1073/pnas.0507581102;
RA Masubelele N.H., Dewitte W., Menges M., Maughan S., Collins C., Huntley R.,
RA Nieuwland J., Scofield S., Murray J.A.H.;
RT "D-type cyclins activate division in the root apex to promote seed
RT germination in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:15694-15699(2005).
CC -!- FUNCTION: May activate cell cycle in the root apical meristem (RAM) and
CC promote embryonic root (radicle) protrusion.
CC {ECO:0000269|PubMed:16227434}.
CC -!- SUBUNIT: Interacts with CDKA-1, CDKB2-1, KRP4/ICK7, KRP5/ICK3,
CC KRP6/ICK4 and KRP7/ICK5. {ECO:0000269|PubMed:10420643,
CC ECO:0000269|PubMed:11449057, ECO:0000269|PubMed:12857813}.
CC -!- INTERACTION:
CC Q8LGA1; P24100: CDKA-1; NbExp=4; IntAct=EBI-1253202, EBI-371713;
CC Q8LGA1; Q8LF80: CDKB2-1; NbExp=4; IntAct=EBI-1253202, EBI-1253579;
CC Q8LGA1; Q94CL9: KRP7; NbExp=2; IntAct=EBI-1253202, EBI-1773344;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q8LGA1-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in shoot apical meristem, leaf primordia
CC vascular tissues and tapetum of anthers. {ECO:0000269|PubMed:10420643,
CC ECO:0000269|PubMed:12857813}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout the cell cycle. Transiently
CC expressed in the root tip during seed germination up to about 21 hours
CC after stratification. Expressed during lateral root primordia
CC formation, vascular tissue development, in fertilized ovules, and
CC torpedo- and heart-stage embryos. {ECO:0000269|PubMed:10420643,
CC ECO:0000269|PubMed:12857813, ECO:0000269|PubMed:16227434}.
CC -!- INDUCTION: By sucrose. {ECO:0000269|PubMed:10420643}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily.
CC {ECO:0000305}.
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DR EMBL; AJ131636; CAB41347.1; -; mRNA.
DR EMBL; AB011479; BAB11564.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98049.1; -; Genomic_DNA.
DR EMBL; AY084386; AAM60963.1; -; mRNA.
DR RefSeq; NP_201345.1; NM_125940.3. [Q8LGA1-1]
DR AlphaFoldDB; Q8LGA1; -.
DR SMR; Q8LGA1; -.
DR BioGRID; 21909; 22.
DR IntAct; Q8LGA1; 10.
DR STRING; 3702.Q8LGA1; -.
DR PaxDb; 3702-AT5G65420-3; -.
DR EnsemblPlants; AT5G65420.1; AT5G65420.1; AT5G65420. [Q8LGA1-1]
DR GeneID; 836667; -.
DR Gramene; AT5G65420.1; AT5G65420.1; AT5G65420. [Q8LGA1-1]
DR KEGG; ath:AT5G65420; -.
DR Araport; AT5G65420; -.
DR TAIR; AT5G65420; CYCD4.
DR eggNOG; KOG0656; Eukaryota.
DR InParanoid; Q8LGA1; -.
DR OMA; CFGSKTH; -.
DR PhylomeDB; Q8LGA1; -.
DR PRO; PR:Q8LGA1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LGA1; baseline and differential.
DR Genevisible; Q8LGA1; AT.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR CDD; cd20543; CYCLIN_AtCycD-like_rpt1; 1.
DR CDD; cd20544; CYCLIN_AtCycD-like_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR048258; Cyclins_cyclin-box.
DR PANTHER; PTHR10177:SF586; CYCLIN-D4-1; 1.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 1.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cyclin;
KW Reference proteome.
FT CHAIN 1..308
FT /note="Cyclin-D4-1"
FT /id="PRO_0000287029"
FT CONFLICT 172
FT /note="K -> R (in Ref. 4; AAM60963)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="V -> A (in Ref. 1; CAB41347)"
FT /evidence="ECO:0000305"
FT CONFLICT 278
FT /note="C -> F (in Ref. 4; AAM60963)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 34716 MW; 96FD929C868DD62F CRC64;
MAEENLELSL LCTESNVDDE GMIVDETPIE ISIPQMGFSQ SESEEIIMEM VEKEKQHLPS
DDYIKRLRSG DLDLNVGRRD ALNWIWKACE VHQFGPLCFC LAMNYLDRFL SVHDLPSGKG
WILQLLAVAC LSLAAKIEET EVPMLIDLQV GDPQFVFEAK SVQRMELLVL NKLKWRLRAI
TPCSYIRYFL RKMSKCDQEP SNTLISRSLQ VIASTTKGID FLEFRPSEVA AAVALSVSGE
LQRVHFDNSS FSPLFSLLQK ERVKKIGEMI ESDGSDLCSQ TPNGVLEVSA CCFSFKTHDS
SSSYTHLS
//
