ID CH19_DROME Reviewed; 173 AA.
AC P07186; A8E6S9; A8E6T1; A8E7A0; Q9VSP3;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 27-MAR-2024, entry version 138.
DE RecName: Full=Chorion protein S19;
DE Flags: Precursor;
GN Name=Cp19; Synonyms=s19; ORFNames=CG6524;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2988878; DOI=10.1007/bf00328464;
RA Wong Y.-C., Pustell J., Spoerel N., Kafatos F.C.;
RT "Coding and potential regulatory sequences of a cluster of chorion genes in
RT Drosophila melanogaster.";
RL Chromosoma 92:124-135(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chorion membrane (egg shell) protein; plays a role in
CC protecting the egg from the environment. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the chorion protein S19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABV82253.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X02497; CAA26330.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF50373.1; -; Genomic_DNA.
DR EMBL; BT030871; ABV82253.1; ALT_FRAME; mRNA.
DR EMBL; BT030873; ABV82255.1; -; mRNA.
DR EMBL; BT030885; ABV82267.1; -; mRNA.
DR EMBL; BT030886; ABV82268.1; -; mRNA.
DR EMBL; BT031042; ABV82424.1; -; mRNA.
DR RefSeq; NP_523980.1; NM_079256.4.
DR AlphaFoldDB; P07186; -.
DR DIP; DIP-17693N; -.
DR IntAct; P07186; 1.
DR STRING; 7227.FBpp0076300; -.
DR PaxDb; 7227-FBpp0076300; -.
DR DNASU; 39000; -.
DR EnsemblMetazoa; FBtr0076573; FBpp0076300; FBgn0000358.
DR GeneID; 39000; -.
DR KEGG; dme:Dmel_CG6524; -.
DR AGR; FB:FBgn0000358; -.
DR CTD; 39000; -.
DR FlyBase; FBgn0000358; Cp19.
DR VEuPathDB; VectorBase:FBgn0000358; -.
DR eggNOG; ENOG502S3GF; Eukaryota.
DR HOGENOM; CLU_1410206_0_0_1; -.
DR InParanoid; P07186; -.
DR OMA; PEYSKVI; -.
DR OrthoDB; 3582654at2759; -.
DR PhylomeDB; P07186; -.
DR SignaLink; P07186; -.
DR BioGRID-ORCS; 39000; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 39000; -.
DR PRO; PR:P07186; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0000358; Expressed in secondary oocyte and 6 other cell types or tissues.
DR Genevisible; P07186; DM.
DR GO; GO:0042600; C:egg chorion; IC:FlyBase.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005213; F:structural constituent of egg chorion; IC:FlyBase.
DR GO; GO:0007304; P:chorion-containing eggshell formation; IEP:FlyBase.
DR InterPro; IPR005649; Chorion_2.
DR Pfam; PF03964; Chorion_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..173
FT /note="Chorion protein S19"
FT /id="PRO_0000089625"
FT CONFLICT 15
FT /note="I -> V (in Ref. 4; ABV82424)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 173 AA; 18525 MW; 209D7BDCBE27569A CRC64;
MNKFATLAVI FCACIVGSCY ANYGGQQSYG QRSYGQDSSA ASAASSAAAA GAEGQQRYER
PVEIIAGGYR GSYAPEILRP IQVSGGYGGE RRGYNGGNYR RAGYGPRWTV QPAGATLLYP
GQNNYKAYVS PPEYSKVILP IRPAAPVAKL FVPENQYGNQ YVSQYSAPRS SGY
//
