ID   CLP1_DROWI              Reviewed;         425 AA.
AC   B4MRZ9;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   RecName: Full=Protein CLP1 homolog {ECO:0000255|HAMAP-Rule:MF_03035};
GN   Name=cbc; ORFNames=GK15921;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC       dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR   EMBL; CH963850; EDW74888.1; -; Genomic_DNA.
DR   RefSeq; XP_002063902.1; XM_002063866.2.
DR   AlphaFoldDB; B4MRZ9; -.
DR   SMR; B4MRZ9; -.
DR   STRING; 7260.B4MRZ9; -.
DR   EnsemblMetazoa; FBtr0246572; FBpp0245064; FBgn0217923.
DR   GeneID; 6640990; -.
DR   KEGG; dwi:6640990; -.
DR   eggNOG; KOG2749; Eukaryota.
DR   HOGENOM; CLU_018195_1_0_1; -.
DR   OMA; VQYVNCH; -.
DR   OrthoDB; 56092at2759; -.
DR   PhylomeDB; B4MRZ9; -.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR   GO; GO:0000214; C:tRNA-intron endonuclease complex; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR   CDD; cd01983; SIMIBI; 1.
DR   Gene3D; 2.60.120.1030; Clp1, DNA binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.330; Pre-mRNA cleavage complex subunit Clp1, C-terminal domain; 1.
DR   HAMAP; MF_03035; Clp1; 1.
DR   InterPro; IPR028606; Clp1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR010655; Clp1_C.
DR   InterPro; IPR038238; Clp1_C_sf.
DR   InterPro; IPR032324; Clp1_N.
DR   InterPro; IPR038239; Clp1_N_sf.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR   PANTHER; PTHR12755:SF6; POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1; 1.
DR   Pfam; PF06807; Clp1; 1.
DR   Pfam; PF16573; CLP1_N; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..425
FT                   /note="Protein CLP1 homolog"
FT                   /id="PRO_0000375187"
FT   BINDING         18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT   BINDING         59
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT   BINDING         121..126
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ   SEQUENCE   425 AA;  47073 MW;  23EBC1F62BBC8864 CRC64;
     MSEDNSQGRD YTLESDSELR FEIEQKDVKV LVTLVNGFAE LFGTELVKKK KYEFGMGAKV
     AIFTYQGCVL HVQGKMDVCY VSKETPMVQY VNCHAALEQF RQEAEEKDAC GPVAMVVGPM
     DVGKSTLCRI LLNYAVRVGR RPLYADIDVG QGAIAIPGNV ATILIERPAS IEEGFPKTAP
     LVYHFGHKSP SGNSVLYNAV VSKMAEVTLN SLSGNKRTQS SGIIVNTCGW VKGSGYAHLL
     HAARAYGAKA IFVLDQERLY NELLRDVPPN VHVVLLPKSG GVVERSKELR HESRDQRIKE
     YFYGNIRAPF YPFSFEVKFQ DLRLYKIGAP PLPDSCMPIG MKAEDNKTKV VAVTPTQSLL
     HHILALSFAE NTDDDVIGTN VAGFCCVTNV DMDRQAVMLL SPQPRPLPPN ALLLWSELQF
     MDNHA
//