ID COG7_DICDI Reviewed; 996 AA.
AC Q54LC8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 7;
DE Short=COG complex subunit 7;
DE AltName: Full=Component of oligomeric Golgi complex 7;
GN Name=cog7; ORFNames=DDB_G0286705;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000250|UniProtKB:P83436}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250|UniProtKB:P83436}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:P83436}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P83436}.
CC -!- SIMILARITY: Belongs to the COG7 family. {ECO:0000305}.
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DR EMBL; AAFI02000089; EAL64108.1; -; Genomic_DNA.
DR RefSeq; XP_637633.1; XM_632541.1.
DR AlphaFoldDB; Q54LC8; -.
DR SMR; Q54LC8; -.
DR STRING; 44689.Q54LC8; -.
DR PaxDb; 44689-DDB0237953; -.
DR EnsemblProtists; EAL64108; EAL64108; DDB_G0286705.
DR GeneID; 8625774; -.
DR KEGG; ddi:DDB_G0286705; -.
DR dictyBase; DDB_G0286705; cog7.
DR eggNOG; KOG4182; Eukaryota.
DR HOGENOM; CLU_300625_0_0_1; -.
DR InParanoid; Q54LC8; -.
DR OMA; FAQVNHS; -.
DR Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DDI-6811438; Intra-Golgi traffic.
DR Reactome; R-DDI-6811440; Retrograde transport at the Trans-Golgi-Network.
DR PRO; PR:Q54LC8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR InterPro; IPR019335; COG7.
DR PANTHER; PTHR21443; CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7; 1.
DR PANTHER; PTHR21443:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7; 1.
DR Pfam; PF10191; COG7; 2.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..996
FT /note="Conserved oligomeric Golgi complex subunit 7"
FT /id="PRO_0000341683"
FT REGION 533..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 996 AA; 113321 MW; 60DC7C6522F16946 CRC64;
MINNELKDIF SSNDFNSKTW INNLLSDCGG SGSSSGNAKS NQQSILTDQN NIKAELEIEN
ICSNYLSKLQ LYQIELNISL ESITSESLLI VPKSIREVDR IRKESLHLKN RIKSISSKIG
EMNNDSPQSM ETVSVIEKLD QVKSRMEISI RSLKEAEKLL SFSKTVDQLF SSNDYLMISD
KLEEVKQSLS VLSDVPEFRE QSKKFNVYQD RLESQLKQPL QQSLQQKDLE SCKNYLKIFT
NIQRQDKFFI YYYQVRIDPL KLLWNSYSSS SSSSSSSSNF HNWLSKFYDE VLVMINSEFN
WLSGLCPIDY IQVLENLIIH LFTTINPNVQ SRIDQAITIA NQTTQQPIKV NELLSIYKTT
CSFLKSLSPI FPNIINSSST PTTSPAVDKL FKVIFEPYKY FQNKFSEYEI KSVKSQLQSI
SPILTLQKKS GGGSGGSGNA DFTNIIKNIE NQFIPKSFQI AQQSIERFFD FTHTTDIDSY
VNTVLNQIFT EISLILRDTI NELKFITGLT TNYIIGSSGT FPNFNQQQQQ INTPSSINGE
VDPVKKLTNS HTRSHSRSGS GSGNSNSNSV GTSATLQNWE YFQGAMNLLQ SIHQLLNKFQ
QFDNSTSLNI IHYLGNSNNS NNSSSNNDND QFICNIRKFL LGKDLNKIQK LQISVQNLEN
IISSPLPLSS SSSVSKDQSI SKKPLLLQES FNQISKLLSI SQHFVYETLI YFIKLKLKEL
PKIVSNEWNN NNNNNNNPSQ NNGGGGGGGL SYISQITDHL LTIPQQLDPY SEEELTRFSL
STSLQYPIKT CSNSEDDFYQ NLLIQYQREK QFDDEQLLIE KLKEKQEQQQ EQQEKEQQQE
KEQQDADQDI NINTNNNNEN DENDEDDELE DGIAHQWITI VAKATEKLYL QTIVEIITLN
EPSCQQLSND IGYLFNVLSA LGVSAEPLLQ KTQSLLEMNR DTFTSFYHQQ LHNNNNNNNN
NNGNSNNNNN NTNNISLLTN AEKNICNLIG KMRNIK
//
