ID COG7_DROME Reviewed; 742 AA.
AC Q9VAD6; Q8SZV9;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 15-NOV-2002, sequence version 2.
DT 27-MAR-2024, entry version 150.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 7;
DE Short=COG complex subunit 7;
DE AltName: Full=Component of oligomeric Golgi complex 7;
GN Name=Cog7; ORFNames=CG31040;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000250|UniProtKB:P83436}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250|UniProtKB:P83436}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:P83436}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P83436}.
CC -!- SIMILARITY: Belongs to the COG7 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF56975.2; -; Genomic_DNA.
DR EMBL; AY069758; AAL39903.1; -; mRNA.
DR RefSeq; NP_651750.1; NM_143493.3.
DR AlphaFoldDB; Q9VAD6; -.
DR SMR; Q9VAD6; -.
DR BioGRID; 68404; 5.
DR ComplexPortal; CPX-2794; COG tethering complex.
DR DIP; DIP-23137N; -.
DR IntAct; Q9VAD6; 1.
DR STRING; 7227.FBpp0084875; -.
DR PaxDb; 7227-FBpp0084875; -.
DR DNASU; 43547; -.
DR EnsemblMetazoa; FBtr0085509; FBpp0084875; FBgn0051040.
DR GeneID; 43547; -.
DR KEGG; dme:Dmel_CG31040; -.
DR UCSC; CG31040-RA; d. melanogaster.
DR AGR; FB:FBgn0051040; -.
DR CTD; 91949; -.
DR FlyBase; FBgn0051040; Cog7.
DR VEuPathDB; VectorBase:FBgn0051040; -.
DR eggNOG; KOG4182; Eukaryota.
DR GeneTree; ENSGT00390000001260; -.
DR HOGENOM; CLU_006044_2_0_1; -.
DR InParanoid; Q9VAD6; -.
DR OMA; FAQVNHS; -.
DR OrthoDB; 455037at2759; -.
DR PhylomeDB; Q9VAD6; -.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811438; Intra-Golgi traffic.
DR Reactome; R-DME-6811440; Retrograde transport at the Trans-Golgi-Network.
DR SignaLink; Q9VAD6; -.
DR BioGRID-ORCS; 43547; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43547; -.
DR PRO; PR:Q9VAD6; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0051040; Expressed in saliva-secreting gland and 23 other cell types or tissues.
DR ExpressionAtlas; Q9VAD6; baseline and differential.
DR Genevisible; Q9VAD6; DM.
DR GO; GO:0036063; C:acroblast; IDA:FlyBase.
DR GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IDA:FlyBase.
DR GO; GO:0000916; P:actomyosin contractile ring contraction; IMP:FlyBase.
DR GO; GO:0007030; P:Golgi organization; IMP:FlyBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:FlyBase.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007112; P:male meiosis cytokinesis; IMP:FlyBase.
DR GO; GO:1903292; P:protein localization to Golgi membrane; IDA:FlyBase.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR InterPro; IPR019335; COG7.
DR PANTHER; PTHR21443; CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7; 1.
DR PANTHER; PTHR21443:SF0; CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7; 1.
DR Pfam; PF10191; COG7; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..742
FT /note="Conserved oligomeric Golgi complex subunit 7"
FT /id="PRO_0000213519"
SQ SEQUENCE 742 AA; 84076 MW; 85998EF365194E39 CRC64;
MDVSALSETT FSPAEWINAN YKKFVEENGR DDSEAASAFI RSYVAKLQLY IFNVNNAVEE
SSRQVVASMP RIAKESAALQ ADVHRLQEKM SAMRLEVAAV QSETGECMAT LERLNTKSQK
LQVAKESLQE SDGWGNLLAE LEDGFERNDL KGVCDKLIAL QKSLHAQEQL PGHAERQTQV
EDFKNRLEAL ASPSVVQCFA EGNTEQAQHF VQIFTSIQRL PQLQQYYRAV QKNFWQQQWK
QTLELQGTES QPQQQQFLTL YYDQLLEHCQ RQVKWCSNLF GENSPQPFLV IAELLPALQP
TRDAHILQLL KTSNERLEML ALFAKVNHSF VLHLNSLLEQ SHITLSEELH RLLGEAIFEY
FHKFIQQYPR LEETQLSTQV DRLSSNQATP SDGVRHLEES TRKLYEWLKE ACERCASITS
DLALCKLITL LNGIFKRQLE SFGRIQRQIG LSLGSSSYAA QSENWSLLQY TMSQLQCLAD
FQVQLHQFEQ DLHTRMVMLS NRLTKPSNRG PITIFQTCDH AARTQLLNSI ADYQQKKSEA
TDSLGIFPQI YATLKSHFAD THDITLNILL QPIETHLAHI RPPVQDHAAS GIEMPSFSFA
PQESITQIGQ YLLTLPQHLE PLLLSPSSLL KQALEVCNIK YTQAIPCADV LLSLVVEQCC
VLYVTQILQI KSLPSSAATQ LSVDIEYLSN VLEELGLSIN LQLSQILTLL KAAPDQYLTL
SSGCEPRLVT AIRQMRNIIS TQ
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