ID CWC21_YARLI Reviewed; 284 AA.
AC Q6C0M9;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Pre-mRNA-splicing factor CWC21;
GN Name=CWC21; OrderedLocusNames=YALI0F23309g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing. May function at or prior to
CC the first catalytic step of splicing at the catalytic center of the
CC spliceosome. May do so by stabilizing the catalytic center or the
CC position of the RNA substrate (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with the NTC complex (or PRP19-associated complex).
CC The NTC complex associates with the spliceosome after the release of
CC the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex
CC reminiscent of a late-stage spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC21 family. {ECO:0000305}.
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DR EMBL; CR382132; CAG78594.1; -; Genomic_DNA.
DR RefSeq; XP_505783.1; XM_505783.1.
DR AlphaFoldDB; Q6C0M9; -.
DR SMR; Q6C0M9; -.
DR STRING; 284591.Q6C0M9; -.
DR EnsemblFungi; CAG78594; CAG78594; YALI0_F23309g.
DR GeneID; 2908777; -.
DR KEGG; yli:YALI0F23309g; -.
DR VEuPathDB; FungiDB:YALI0_F23309g; -.
DR HOGENOM; CLU_980723_0_0_1; -.
DR InParanoid; Q6C0M9; -.
DR OMA; RDYQEGS; -.
DR OrthoDB; 25337at2759; -.
DR Proteomes; UP000001300; Chromosome F.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd21372; cwf21_CWC21-like; 1.
DR Gene3D; 6.10.140.420; -; 1.
DR InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR PANTHER; PTHR36562:SF5; RHODANESE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR36562; SERINE/ARGININE REPETITIVE MATRIX 2; 1.
DR Pfam; PF08312; cwf21; 1.
DR SMART; SM01115; cwf21; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Spliceosome.
FT CHAIN 1..284
FT /note="Pre-mRNA-splicing factor CWC21"
FT /id="PRO_0000123504"
FT DOMAIN 70..114
FT /note="CWF21"
FT /evidence="ECO:0000255"
FT REGION 148..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..118
FT /evidence="ECO:0000255"
FT COMPBIAS 148..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 284 AA; 33651 MW; 11D3454B49EC12DA CRC64;
MSYNGIGLST PRGSATSGHI QTNISNRAFQ STNHRGEFAH HEMTDEQDKR LNKKLDRDYA
ADRQADVELL EHERKRKVEV ACMELQDKLE EEGQKGEEEI EEEVNTLRRQ LTLKMARELD
VRTTIVSADR EALRKNYHKA AVIKQQEMDR MRDAFDTTKN LDDRGRDRPR NRQRQNREKS
PVRDTRRSRS ARERSPSRRG RRPRRYSVTE DVRTSEVISE RQGSGSPCRR ADSRSRSRSP
ERGSRRKSYR ERSRSRSRER SERRGRRDSV REREQDRSRS PLPY
//
