ID CXXC4_XENTR Reviewed; 188 AA.
AC Q0VFP6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=CXXC-type zinc finger protein 4;
GN Name=cxxc4;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a negative regulator of the Wnt signaling pathway
CC required for anterior neural structure formation (By similarity). Binds
CC preferentially to DNA containing cytidine-phosphate-guanosine (CpG)
CC dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and
CC hemimethylated-hydroxymethyl-CpG (By similarity).
CC {ECO:0000250|UniProtKB:Q800L6, ECO:0000250|UniProtKB:Q9H2H0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9EQC9}.
CC -!- DOMAIN: The CXXC zinc finger mediates binding to CpG-DNA.
CC {ECO:0000250|UniProtKB:Q9H2H0}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI18751.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC118750; AAI18751.1; ALT_INIT; mRNA.
DR RefSeq; NP_001072200.2; NM_001078732.2.
DR AlphaFoldDB; Q0VFP6; -.
DR SMR; Q0VFP6; -.
DR STRING; 8364.ENSXETP00000003190; -.
DR DNASU; 779646; -.
DR GeneID; 779646; -.
DR KEGG; xtr:779646; -.
DR AGR; Xenbase:XB-GENE-479477; -.
DR CTD; 80319; -.
DR InParanoid; Q0VFP6; -.
DR OrthoDB; 4203385at2759; -.
DR Proteomes; UP000008143; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0007352; P:zygotic specification of dorsal/ventral axis; IDA:BHF-UCL.
DR InterPro; IPR040388; CXXC4/CXXC5.
DR InterPro; IPR002857; Znf_CXXC.
DR PANTHER; PTHR13419:SF1; CXXC FINGER PROTEIN 4; 1.
DR PANTHER; PTHR13419; ZINC FINGER-CONTAINING; 1.
DR Pfam; PF02008; zf-CXXC; 1.
DR PROSITE; PS51058; ZF_CXXC; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Metal-binding; Reference proteome;
KW Wnt signaling pathway; Zinc; Zinc-finger.
FT CHAIN 1..188
FT /note="CXXC-type zinc finger protein 4"
FT /id="PRO_0000317546"
FT ZN_FING 122..163
FT /note="CXXC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 129
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT BINDING 132
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT BINDING 135
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT BINDING 141
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT BINDING 144
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT BINDING 147
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT BINDING 157
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
FT BINDING 162
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00509"
SQ SEQUENCE 188 AA; 20037 MW; 28E8F36DECF2A7F8 CRC64;
MHRNDSQRLG KPGGAPESLQ MANNNFLSTL SPEHCRPLAG ECMNKLKCGA AEAEIMNLPE
RVGTFSAIPA LGGISLPPGV IVMTALHSPA AASAAVTDSA FQIANLADCP QNNSSGAGGN
PAKKKRKRCG VCVPCKRLIN CGVCSSCRNR KTGHQICKFR KCEELKKKPG TSLERTPVPS
AEAFRWFF
//
