ID D0A8V8_TRYB9 Unreviewed; 650 AA.
AC D0A8V8;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Fe2OG dioxygenase domain-containing protein {ECO:0000259|PROSITE:PS51471};
GN ORFNames=TbgDal_XI12280 {ECO:0000313|EMBL:CBH18109.1};
OS Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH18109.1, ECO:0000313|Proteomes:UP000002316};
RN [1] {ECO:0000313|Proteomes:UP000002316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA Barry J.D., Berriman M., Hertz-Fowler C.;
RT "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT chronic human african trypanosomiasis.";
RL PLoS Negl. Trop. Dis. 4:E658-E658(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the alkB family.
CC {ECO:0000256|ARBA:ARBA00007879}.
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DR EMBL; FN554974; CBH18109.1; -; Genomic_DNA.
DR RefSeq; XP_011780373.1; XM_011782071.1.
DR AlphaFoldDB; D0A8V8; -.
DR GeneID; 23866385; -.
DR KEGG; tbg:TbgDal_XI12280; -.
DR VEuPathDB; TriTrypDB:Tbg972.11.12280; -.
DR OrthoDB; 169579at2759; -.
DR Proteomes; UP000002316; Chromosome 11.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR032862; ALKBH6.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR46030; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6; 1.
DR PANTHER; PTHR46030:SF1; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 360..500
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 20..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 574..643
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 650 AA; 71719 MW; B88758972035ACD2 CRC64;
MRRCLILPVL TTASKSSFAS CRHSSSGDGR NGGVGSSASS SATTIRESMK SAGFNFNTPN
FCLEGATESD VADTAGELIT SPVTSLNFVR DMYGPWLVLT EEIQGELFID HDKMVYLRPA
NGLGFGVGRI DTGEPCSSGT AFLMSLEWYT YPATTSMPPN NACKTEVTGV VKHVHSSSMD
YSTFTLVASW RSSSGTSGKF NAAKLSPWDP VGGVKRWTPN GDLMQVFHQV FPTPLRLTSH
IKRATAARQV GSRSGGLGEG ELGSSPHHLS LEQYRVGELP DLYYIPNYIS EEEEQEMMEA
VRSTPRELKT QLTKRTVQEW GCSMCETCNK SFVSDRNMPP WVEACTDMQV YDGIFTPSVF
PNSVRVHEYH PHEGIAPHCD GPIYVPRVSV LSLGTPCVMF FYSRREPYSE PMEHYNDTFR
FKEGIAKESP IQSVVLEPRS LLVFAGDVFH YYPHGTCDRK IVPLTTEVAG RVVNRHLLQD
PDIKEVHKGF RVSVTTRNLL PRCNHQPERA EYGMKRAWFI YNQLPVPQQL FTSPPLAPDA
KTGNAGGEEK AKPFDASAGK SAAGSAHPGT DENMANIEKK LDQLLKQQNA LSQQLDEVRQ
LIAGDAGFRH EVSTVLGHLT STVLQIESKL EDLEDNRARE MGETGGQTTA
//
