ID D0EWS1_DANRE Unreviewed; 1430 AA.
AC D0EWS1;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Low density lipoprotein-related protein 6 {ECO:0000313|EMBL:ACX46988.1};
DE SubName: Full=Low-density lipoprotein receptor-related protein 5 {ECO:0000313|RefSeq:NP_001170929.1};
GN Name=lrp5 {ECO:0000313|RefSeq:NP_001170929.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050518-2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ACX46988.1};
RN [1] {ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16237125;
RA Dixon R.J., Eperon I.C., Hall L., Samani N.J.;
RT "A genome-wide survey demonstrates widespread non-linear mRNA in expressed
RT sequences from multiple species.";
RL Nucleic Acids Res. 33:5904-5913(2005).
RN [2] {ECO:0000313|EMBL:ACX46988.1, ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19801552; DOI=10.1074/jbc.M109.047456;
RA Chen M., Philipp M., Wang J., Premont R.T., Garrison T.R., Caron M.G.,
RA Lefkowitz R.J., Chen W.;
RT "G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt
RT pathway.";
RL J. Biol. Chem. 284:35040-35048(2009).
RN [3] {ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21911394;
RA Ramachandran R., Zhao X.F., Goldman D.;
RT "Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen
RT synthase kinase-3beta inhibition is sufficient for zebrafish retina
RT regeneration.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:15858-15863(2011).
RN [4] {ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23484855;
RA Lu H., Ma J., Yang Y., Shi W., Luo L.;
RT "EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic
RT development.";
RL Dev. Cell 24:543-553(2013).
RN [5] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24485658;
RA Wehner D., Cizelsky W., Vasudevaro M.D., Ozhan G., Haase C.,
RA Kagermeier-Schenk B., Roder A., Dorsky R.I., Moro E., Argenton F., Kuhl M.,
RA Weidinger G.;
RT "Wnt/beta-catenin signaling defines organizing centers that orchestrate
RT growth and differentiation of the regenerating zebrafish caudal fin.";
RL Cell Rep. 6:467-481(2014).
RN [7] {ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [8] {ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27193966;
RA Cui Y., Lv S., Liu J., Nie S., Chen J., Dong Q., Huang C., Yang D.;
RT "Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in
RT zebrafish.";
RL Hum Exp Toxicol 36:207-217(2017).
RN [9] {ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28677207;
RA Xia W., Hu J., Liu F., Ma J., Sun S., Zhang J., Jin K., Huang J., Jiang N.,
RA Wang X., Li W., Ma Z., Ma D.;
RT "New role of LRP5, associated with nonsyndromic autosomal-recessive
RT hereditary hearing loss.";
RL Hum. Mutat. 38:1421-1431(2017).
RN [10] {ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29266316;
RA So J., Khaliq M., Evason K., Ninov N., Martin B.L., Stainier D.Y.R.,
RA Shin D.;
RT "Wnt/beta-catenin signaling controls intrahepatic biliary network formation
RT in zebrafish by regulating notch activity.";
RL Hepatology 67:2352-2366(2018).
RN [11] {ECO:0000313|RefSeq:NP_001170929.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29511374; DOI=10.7150/ijms.23054;
RA Du Z., Ma H.L., Zhang Z.Y., Zheng J.W., Wang Y.A.;
RT "Transgenic Expression of A Venous Malformation Related Mutation, TIE2-
RT R849W, Significantly Induces Multiple Malformations of Zebrafish.";
RL Int. J. Med. Sci. 15:385-394(2018).
RN [12] {ECO:0000313|RefSeq:NP_001170929.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; GQ903573; ACX46988.1; -; mRNA.
DR RefSeq; NP_001170929.1; NM_001177458.1.
DR GeneID; 568518; -.
DR KEGG; dre:568518; -.
DR AGR; ZFIN:ZDB-GENE-050518-2; -.
DR CTD; 4041; -.
DR ZFIN; ZDB-GENE-050518-2; lrp5.
DR OrthoDB; 3107655at2759; -.
DR PhylomeDB; D0EWS1; -.
DR Proteomes; UP000000437; Chromosome 25.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042813; F:Wnt receptor activity; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR GO; GO:0035676; P:anterior lateral line neuromast hair cell development; IMP:ZFIN.
DR GO; GO:0030282; P:bone mineralization; IMP:ZFIN.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:ZFIN.
DR GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR GO; GO:0001889; P:liver development; IMP:ZFIN.
DR GO; GO:0001755; P:neural crest cell migration; IMP:ZFIN.
DR GO; GO:0032474; P:otolith morphogenesis; IMP:ZFIN.
DR GO; GO:0035677; P:posterior lateral line neuromast hair cell development; IMP:ZFIN.
DR GO; GO:0030500; P:regulation of bone mineralization; IMP:ZFIN.
DR GO; GO:0045124; P:regulation of bone resorption; IMP:ZFIN.
DR GO; GO:0030111; P:regulation of Wnt signaling pathway; IMP:ZFIN.
DR GO; GO:0007605; P:sensory perception of sound; IMP:ZFIN.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF16; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 8.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 17.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 11.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:ACX46988.1,
KW ECO:0000313|RefSeq:NP_001170929.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:D0EWS1};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:NP_001170929.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1203..1223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 27..69
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 118..157
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 205..247
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 248..290
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 291..334
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 335..377
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 424..461
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 507..549
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 550..592
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 593..635
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 676..718
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 725..762
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 896..940
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 941..983
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1033..1077
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 1114..1150
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 822..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1380..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1288..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1397..1411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1430
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1097..1112
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1115..1127
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1122..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1134..1149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1153..1165
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1160..1178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1172..1187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1430 AA; 160013 MW; FD1FF5E16991B700 CRC64;
MDGSNRQIIV QKQIYWPNGL TIDLDEQKLY WADAKLSFIH RANLDGTSRE AVVEGSLTHP
FALTLYDETL YWTDWQTRSI HACNKHSGEK HREILNGIYS PMDIQVLGQE RQPNIQTPCS
ERNGGCSHLC LLSPIPPFYS CACPTGVKLK EDGKTCRPGA EQVLLLARRT DLRRISLDLP
DFTDIVLQVN DIRHAIAIDY DPVEGYVYWT DDELRAIRRA RIDGSDAQTL ITNEINHPDG
IAVDWVARNL YWTDTGTDRI EVTRLNGTSR RVLISENLDE PRAIVLDPIN GYMYWTDWGE
LPKIERANLD GTDRVVLLNT SLGWPNGLAI DYIAGKLYWG DAKTDKIEVI NVDGTNRMTI
LEDKLPHIFG FTLLGEYIYW TDWQRRSIER VHIANSTREV IVEQLPDLMG LKATKVMEAE
GTNGCAENNG GCSHLCFHRP QGLSCACPMG LELLSDLRTC VVPEAFLLFT NRADIRSISL
GTNSNDVPIP LTGVKEASAL DFDVLENRIY WTDVSTKTIS RAFMNGSSVE PVIEFGLDYP
EGMAVDWMGR NLYWADTGTN RIEVARLDGQ YRQVLVCKDL DNPRSLALDP ANGYMYWTEW
GGRPRIARAH MDGSNIVTLV DKVGRANGLT IDYIDQRLYW TDLDTCMIES TNMQSLQREI
VADDLPHPFG LTQYRDYIYW TDWNLRSIER ADKRSGLNRT VVQGHLEYVM DILVFHSSRQ
DGANDCSQNN GQCAHLCLAS PSGAQCRCAS HYTLEANGRN CSSPSSFLLF SQKSSISRMV
LGEQSPDMIL PIHVMKNLRA ISFDPLERLV YWVDGRQNIR RSRDDGTQAS TVMTPNSDHP
KQPHDLSLDP YSRTVYWTCE TTNTINIHRM DGHVIGEVLK DDVDKPRAIV VNAEKGYMYF
TTVQERSAKI EGASLDGTER ESLFTTSLIR PVALALDNKL GKLFWVDADL KRIESSDLSG
ANRIVLQDSN ILQPVGLTVL GDHLYWIDKQ QQMIERVDKL TGEKRTRIQG RLQYLTGIHA
VQYMETDEFA THPCSRDNGG CSHICIAKGD GTPRCSCPMH LVLLQNLLSC GEPPTCSSEQ
FTCATGEIDC IPMAWRCDGI AECADNSDEM NCPICSKLQF QCDKGQCVDI QVRCNGEPDC
ADGSDEQDCE TICLSNQFRC GNSQCILKKQ QCDSFPDCTD ESDERFCDFP PPPNDLPRHT
STIGPVIGII LSVFVMGGMC FVCQRVVCRH YKGPNGGFPH EYISGTPHVP LNFIAPTNSQ
HGKGISCGKS MMSSVSLMGS SSSGAPLYDR NHVTGASSSS SSSTKGAFYP QMLNPPPSPA
TDRSLYNAEV FYSSNSPSTT RSYRPYLMRG VAPPTTPCST DVCDSDYTTS RWKSNKYYMD
LNSDSDPYPP PPTPRSQYMS AEESCPPSPS TERSYFHLCP PPPSPCTDSS
//
