ID D0KVZ0_HALNC Unreviewed; 285 AA.
AC D0KVZ0;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=6-phosphogluconate dehydrogenase NAD-binding protein {ECO:0000313|EMBL:ACX94917.1};
GN OrderedLocusNames=Hneap_0051 {ECO:0000313|EMBL:ACX94917.1};
OS Halothiobacillus neapolitanus (strain ATCC 23641 / c2) (Thiobacillus
OS neapolitanus).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Halothiobacillaceae; Halothiobacillus.
OX NCBI_TaxID=555778 {ECO:0000313|EMBL:ACX94917.1, ECO:0000313|Proteomes:UP000009102};
RN [1] {ECO:0000313|EMBL:ACX94917.1, ECO:0000313|Proteomes:UP000009102}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23641 / c2 {ECO:0000313|Proteomes:UP000009102};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Davenport K., Brettin T., Detter J.C., Han C.,
RA Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA Kerfeld C., Cannon G., Heinhort S.;
RT "Complete sequence of Halothiobacillus neapolitanus c2.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001801; ACX94917.1; -; Genomic_DNA.
DR RefSeq; WP_012822954.1; NC_013422.1.
DR AlphaFoldDB; D0KVZ0; -.
DR STRING; 555778.Hneap_0051; -.
DR KEGG; hna:Hneap_0051; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_0_8_6; -.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000009102; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580:SF10; GLYOXYLATE_SUCCINIC SEMIALDEHYDE REDUCTASE 2, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000009102}.
FT DOMAIN 2..152
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 158..275
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 164
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 285 AA; 30072 MW; 7AA2BF18B0682977 CRC64;
MNIAVLGLGL MGRAIAERLV KAGMTVRGYN RSALSAPPTG VTMSESVAAA VEPSDIVWVM
LADFAACESV LLAENPWDLF KNKLIINGAT IGPEQSRALA ESIKQLGGHY LESPVLGSTP
QAETGTLQIL VGGDPADVAV ADPVLKALGK PTHFGGIGQG AAVKLAMNQL IGSLTAAFSM
SLGLVEREGV DVDTFMNTLR DSALYAPTFD KKLDRMRTRD FAAANFPLKH LLKDIRLFTE
VAGAQQIDAR MLDGLARILA DGVTAGHADE DYSALFGQIV PNITP
//
