ID D0LS57_HALO1 Unreviewed; 463 AA.
AC D0LS57;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Epoxidase {ECO:0000313|EMBL:AMM72022.1};
DE SubName: Full=Monooxygenase FAD-binding protein {ECO:0000313|EMBL:ACY13754.1};
GN Name=hliU {ECO:0000313|EMBL:AMM72022.1};
GN OrderedLocusNames=Hoch_1187 {ECO:0000313|EMBL:ACY13754.1};
OS Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2).
OC Bacteria; Myxococcota; Polyangia; Haliangiales; Kofleriaceae; Haliangium.
OX NCBI_TaxID=502025 {ECO:0000313|EMBL:ACY13754.1, ECO:0000313|Proteomes:UP000001880};
RN [1] {ECO:0000313|EMBL:ACY13754.1, ECO:0000313|Proteomes:UP000001880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14365 {ECO:0000313|EMBL:ACY13754.1}, and DSM 14365 / CIP
RC 107738 / JCM 11303 / AJ 13395 / SMP-2
RC {ECO:0000313|Proteomes:UP000001880};
RX PubMed=21304682; DOI=10.4056/sigs.69.1277;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ivanova N., Daum C., Lang E., Abt B., Kopitz M., Saunders E., Lapidus A.,
RA Lucas S., Glavina Del Rio T., Nolan M., Tice H., Copeland A., Cheng J.F.,
RA Chen F., Bruce D., Goodwin L., Pitluck S., Mavromatis K., Pati A.,
RA Mikhailova N., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Detter J.C., Brettin T., Rohde M., Goker M., Bristow J.,
RA Markowitz V., Eisen J.A., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Haliangium ochraceum type strain (SMP-2).";
RL Stand. Genomic Sci. 2:96-106(2010).
RN [2] {ECO:0000313|EMBL:AMM72022.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SMP-2 {ECO:0000313|EMBL:AMM72022.1};
RX PubMed=26915413; DOI=10.1038/srep22091;
RA Sun Y., Feng Z., Tomura T., Suzuki A., Miyano S., Tsuge T., Mori H.,
RA Suh J.W., Iizuka T., Fudou R., Ojika M.;
RT "Heterologous Production of the Marine Myxobacterial Antibiotic Haliangicin
RT and Its Unnatural Analogues Generated by Engineering of the Biochemical
RT Pathway.";
RL Sci. Rep. 6:22091-22091(2016).
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DR EMBL; CP001804; ACY13754.1; -; Genomic_DNA.
DR EMBL; KU523558; AMM72022.1; -; Genomic_DNA.
DR AlphaFoldDB; D0LS57; -.
DR STRING; 502025.Hoch_1187; -.
DR KEGG; hoh:Hoch_1187; -.
DR eggNOG; COG0654; Bacteria.
DR HOGENOM; CLU_028028_2_0_7; -.
DR OrthoDB; 9790035at2; -.
DR Proteomes; UP000001880; Chromosome.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR43422; THIAMINE THIAZOLE SYNTHASE; 1.
DR PANTHER; PTHR43422:SF3; THIAMINE THIAZOLE SYNTHASE; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW Monooxygenase {ECO:0000313|EMBL:ACY13754.1};
KW Oxidoreductase {ECO:0000313|EMBL:ACY13754.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001880}.
FT DOMAIN 18..358
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
SQ SEQUENCE 463 AA; 51312 MW; 3ED50D4B0F85B6A5 CRC64;
MSFLTNFSRR TPDRADHAIV IGGGIAGMLA ARVLCEHAYR VTVIERDCVP DEPTVRSGVP
QARHVHQMLA RGRAELEMLF PGLERALLAD GAVPVRWGDD VSAVAWGREM PRTPLGVQTY
SCSRELLESH LRQRVRARPT ISFIESCEVT ALETDDAGSR VVGVQLRPHG AGPHKDIPKR
LEATWVVDTS GRSSRAVRWL DELDYPTPEE TIIDAQLGYA SAYFRLANEP PWKMLIIGSD
PPAQTRSSVV AAVEDGRWMV TMTGVGDDQP PTDEEAFLAY AASLPVPGFA DMLRAAERLT
PIRGFRRTRN HRRHFEKMAR WPENFFVLGD AACSVNPVYG QGMTAAALGA RALDSCLARR
GSEPTVAHRF QRELAQAVDT IWLLATSADH RMPTVESSEN DWLARIRHAY IDRLTRSFAD
RPRAHGAFVR VSHLLDSPAT LFHPKILADV FVPGRAGHES SPK
//
