ID D0MTJ9_PHYIT Unreviewed; 1069 AA.
AC D0MTJ9;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Nardilysin, putative {ECO:0000313|EMBL:EEY61296.1};
GN ORFNames=PITG_01569 {ECO:0000313|EMBL:EEY61296.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY61296.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; DS028119; EEY61296.1; -; Genomic_DNA.
DR RefSeq; XP_002908213.1; XM_002908167.1.
DR AlphaFoldDB; D0MTJ9; -.
DR STRING; 403677.D0MTJ9; -.
DR EnsemblProtists; PITG_01569T0; PITG_01569T0; PITG_01569.
DR GeneID; 9468911; -.
DR KEGG; pif:PITG_01569; -.
DR VEuPathDB; FungiDB:PITG_01569; -.
DR eggNOG; KOG0959; Eukaryota.
DR HOGENOM; CLU_004639_1_1_1; -.
DR InParanoid; D0MTJ9; -.
DR OMA; INQVMEH; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 110..230
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 266..451
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 459..743
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 771..927
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 1046..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1069
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 120939 MW; D40039C4DFD19A85 CRC64;
MWRASRLHFV SSKSLRSSAS RNESVSGCPS VLSRTVRSVM RLMCSTLMPR PSFMASISSS
KSPNDQKKYR LLTLPNELQV LLISTAEVAH VAAADESSFD DNEEEREGAP SRRAGACLTV
GVGSFAEPEA LPGLAHYLEH MLFMGSEKYP DENEFESFLS AHGGYSNGAT DNEVTSYTFE
VGPAHLEPAL DMFAHFFISP LLKAEAMDRE LSAIESEFSQ ATQNDRIRTQ QVLCDVSPAT
HPYHRFSWGN RKSLQELPEQ MGVDVRQQIL GFYDKYYSSN IMKLVVCGEN TLDELEQWVT
KSFSAIPNKH VDVPSFASTG PPFGAQGAGA PFLCKIVPVR DIHTLHLDWM IPPVLGLHHQ
KPSDYIASLL GHESEGSVLS HLKQRGWISA VTAGVTDTDG YDCGSYAAKF DITMKLTLEG
ISHWEDIAHA VFEYLHMLRV NGCPEWVFDE LAALADISFR FQEEDSAVEK CEELGEIMQS
MFRVAPDDIL RYDLLKGVFK KELTEEVLSH LTAESVCVSI VSQRFEESAE FQTQVIEEEW
FGVRYSRENI ADAVIQRWKR AGTNPKLHLP RPNQFIPRDF SLVDSIDAED LVCGATKFGK
LWYKPDRVFA TPRAHVALLL HLPTVVANVD NWVLTQLYVK LVRDALNEYA YHANVAELMY
SLQVKDSGLE LIFGGFNDKL HILVEVVVAA LFGTEINEAR FEVMREELMR ESKNAITKVA
QKAKYLRLQL LEKRSFALEE CLDSIEDATE ESLKKYVANE LWAGKAWLAS FAHGNIFHSV
ASKMVASVET QLQRVSAPLE LHDFPRRLIN AIPQTPVGFL LKERSENKSE TNTQVELYYQ
IGPLTLRSLA YADLLHQLME EPLFDTLRTK QELGYDVSCT VRVTNGILGF GVMVQSSLFA
AEYISACVDR FMIDFEEAIE MMADEHFHDH VQAQILLKLE PDHNLLETTH HYWYEITSRR
LAFDLDAQLA KEMETLTKSE MAQHYREWIL QSPKKLIVQV IGRGNPAEKI AQKTRKNATE
AELAELRALP RPIRIRDLCL FKSELPSYPD PIDEINTGKT REEDKRQEL
//
