ID D0MZJ4_PHYIT Unreviewed; 941 AA.
AC D0MZJ4;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=GPN-loop GTPase 3 {ECO:0000256|ARBA:ARBA00014587};
GN ORFNames=PITG_03169 {ECO:0000313|EMBL:EEY65657.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY65657.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS028121; EEY65657.1; -; Genomic_DNA.
DR RefSeq; XP_002906256.1; XM_002906210.1.
DR AlphaFoldDB; D0MZJ4; -.
DR STRING; 403677.D0MZJ4; -.
DR EnsemblProtists; PITG_03169T0; PITG_03169T0; PITG_03169.
DR GeneID; 9464580; -.
DR KEGG; pif:PITG_03169; -.
DR VEuPathDB; FungiDB:PITG_03169; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG1534; Eukaryota.
DR HOGENOM; CLU_011254_0_0_1; -.
DR InParanoid; D0MZJ4; -.
DR OMA; CSHVSVE; -.
DR OrthoDB; 74530at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd17872; GPN3; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030228; Gpn3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR21231:SF7; GPN-LOOP GTPASE 3; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT REPEAT 416..447
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 545..622
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 25..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 941 AA; 105427 MW; 8B62487BF05007E4 CRC64;
MLETRTSNEL DLAYMPYHEG LVNHNAPPVR GSLSVRVSNQ QQHSQQSPYY GDSDDDDVSD
DPAWMAAPRG SLQPAFPSNL MKKASNVSIT DTQDSSPKSP DTDPISSAGE EDEQDKQRDD
KKDDDEDEDD DDYFPPTMPK VKSPQPSSRR KSPPHSSGRR SLNNSVDDKL TTDLKLRKCK
SMPMNQSPAN PADNNKMVNL GVPRNSRGNS EIDRLSVEKK ATDAPTVPEV ASHPVGGSNN
GHRDSMMRYR PSDLKPQDLK TAMMSRDSLA PENFESSRSV DMYASSRSSN MGIDSIRSND
QFGSSRSSNV FDSSRGVDPF ASTRSTDLVS GRGSVMHFGP RVTEEGLSDY LRAVKTGNIQ
LLRTCLLDRN TDFTERDPVH GQSAMHIAVR FGQLHAVQLL CGKKTRGLLI DAVDNRQNTP
LHLASAKSRR ITKYLLEHGA DASRVNNRNQ TPLAVHIVTT KRDDPLIAEM LLQHKTDPNG
ALGNSTLLHK ALDLKLYEVA YRLVRHGGRL DAKDAQGHMV FEKVDRKVLR QLCGKISYPP
VWVPNMERKG CMICLRNFSR LGVGVRRHHC RHCGRLICGR CSHVSVESEA FPSTFIGHID
RNASDERSNL KRVCKTCSSV FDERAKLGKE SSPGGSHKWS DAFMDRVVGC SWDEIEPALC
CWPWSSFRKR RNWSSFIMRC CQMVMGPAGT GKSTYCNNMH EFCAASGRMT YVVNLDPAAD
HFDYPVAFDI RDLISVEDVM EELGYGPNGG LIYCMEYLVQ NLDWLQDLLG EYSDEDYFIF
DCPGQIELYS HLPVMKQLCD SLKDWGFNIC CVYLIDSLFI VDPTKFISGV LCSLSAMVQL
ELPHINVLTK CDLVDEKEMS KYLDPSEGYL LENLANSTDP KWRPLSTAIC NVINDFSMVA
FVPMNINREE SIETVLMHVD HAINYGDDLE PQEPKSNEVD E
//
