ID D0NGD4_PHYIT Unreviewed; 712 AA.
AC D0NGD4;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=PITG_11182 {ECO:0000313|EMBL:EEY57335.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY57335.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS028136; EEY57335.1; -; Genomic_DNA.
DR RefSeq; XP_002901945.1; XM_002901899.1.
DR AlphaFoldDB; D0NGD4; -.
DR STRING; 403677.D0NGD4; -.
DR EnsemblProtists; PITG_11182T0; PITG_11182T0; PITG_11182.
DR GeneID; 9476339; -.
DR KEGG; pif:PITG_11182; -.
DR VEuPathDB; FungiDB:PITG_11182; -.
DR eggNOG; ENOG502RWP0; Eukaryota.
DR HOGENOM; CLU_452364_0_0_1; -.
DR InParanoid; D0NGD4; -.
DR OMA; DCHANGL; -.
DR OrthoDB; 91471at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd00821; PH; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14336:SF8; DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE; 1.
DR PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 3.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 293..383
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 514..604
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 239..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 79050 MW; 01734F81881A310C CRC64;
MVTQRVAPIH ADDASAYHAG KTALNAMLTR QDESPHSVEQ AEALDDGYDD TAPLGLAVNT
RNYQALLDNL ARRRRTGSGA SLVSSGSVSP GYQRQTVAVW QQQMGNQLES LSLVQTVAVD
EEEEGEEEGD HTVVGLPVDT RNYEAIVSGS RPIRSDPGTF NLMNRRATVA TMPQMPQRVK
DSEEMRPDQN QAAVVNTGDA GEDDAVMGLP ISTGNYVAYL AGQQGSGIQQ AGHRNRGYSN
LAQEKEPRVS DPYLSSSRRG RSPDSYTTAP SNNNQDNTRP SCFDNRRASN AAYVPHSGWV
FIQHGAFKTW KRYYAVLSGT EFKYSKGAGQ SPKGFGLLMS VHKLDSLRYG LLLEFGDGGT
LQIRCPSEKE FEQWHGAMEK VIERNQNLNS QSKTSYTLTA SEQHEGYLFK QEKNKAWKRC
FFVVRIDGYI ECRDHDHGTA DRKCSGYIKA VSFADCHANG LAIELSTGIS MVCYADSYDE
QMLWYGAISA AATANGKTAQ PKTSVKSSYI QTALSNHAGW LYKQAGLFKG WKRLYFTLHG
VELAYAKDTN SETVLSDKAH SVEEWEGHAN GLLIRLISGR VWKVHAESYE TAKRWRSVIS
SACRHAETFN LKKYLNSRRR KKLRPVFGGW LTDVRKGSRL RRFYVMDGAT LGVANDVDNQ
LERLGTVVDV GSTRDLECGI VFTLANGNKL KVNCDSLADS RCWYDCLNFS LK
//
