ID D0NK36_PHYIT Unreviewed; 1194 AA.
AC D0NK36;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=PITG_13017 {ECO:0000313|EMBL:EEY59873.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY59873.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; DS028142; EEY59873.1; -; Genomic_DNA.
DR RefSeq; XP_002900558.1; XM_002900512.1.
DR AlphaFoldDB; D0NK36; -.
DR STRING; 403677.D0NK36; -.
DR EnsemblProtists; PITG_13017T0; PITG_13017T0; PITG_13017.
DR GeneID; 9474520; -.
DR KEGG; pif:PITG_13017; -.
DR VEuPathDB; FungiDB:PITG_13017; -.
DR eggNOG; KOG0926; Eukaryota.
DR HOGENOM; CLU_001832_0_0_1; -.
DR InParanoid; D0NK36; -.
DR OMA; KYAYHCA; -.
DR OrthoDB; 5490433at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17982; DEXHc_DHX37; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF99; ATP-DEPENDENT RNA HELICASE DHX37-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EEY59873.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643}.
FT DOMAIN 279..478
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 573..757
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1194 AA; 134210 MW; FBC4DB97141FFCFC CRC64;
MAAKKRKQSG NAKAKKKAKT AKADSGLLSA ELLEEMGGED AGGALVLPGR REKKQKAEKI
PEELIEQAQH MSKSKRKKLE AIAARKVKEA RRADLYKSLE KQQLSQDQMK LLYSTSQMGH
KETLRERLKR SLNRQKAGIE LRSVVRRKQP YPTSDATSVM TLQQIEEDPE QEAKRTSSQS
AAMTKLDALR KQNEEKRRLR ALSGKPQPAA ASKQEEPSVN PADVYVPKPI VLKTPQEMRQ
LSKKMSLSYK NTLVTLSRKP EIQMARMQLP VCSSEQEIME SITENDVIIL CGETGSGKTT
QVPQFLYEAG YGHPDHPSNS GRIGVTQPRR VAAVSTAKRV AEELNVPFGA PKGHVGYQIR
YDAEHVSEHT RIKFMTDGIL LKEIQQDFLL RQYSILLLDE AHERNVNTDI LIGLLSRIAP
LRAQMSREEE EAYQALSEDE KETADKPIKP LKLVIMSATL RVEDFTQNQR LFPSPPPVLR
VDARQYPVTI HFNKRTELDN YVDEAYKKVI KIHKKLPEGG VLVFLTGQRE ILQLCRKLSR
AYSVAARHKK AAALKCSRAF RAQRRPTDKS KDDFLREHDD IEEEADLEDD QVYGNDVDDE
DIAYNLEEQE RNSDDEDEDV EELAVPYLHV LPLYSLLPND EQMKVFDTPP ENHRLVVVAT
NVAETSLTIP GVKYVVDAGR TKERVFDLAN GISSFKVQWI SKASADQRAG RAGRTGPGHC
YRLYSSAVYD TEFQKFSSPE ILCQPIDDLV LQMKAMGIHN VSQFPFPTPP DRLAVKNALA
TLVNLGAVSP GDDEAITGLG RALVKFPVAA RFAKMLLLAQ KLEVVEYTIA IVAGLSGHSP
FIHALDQMRK HAQWIDQESD VLSLLRAAGA YAYTGGSSQF CKDNHLHEKT MQNMLKLRQQ
LTRIVNKLYA EDTVELKPKM PPPDLDTQAV LRQIVAAGFL DQVAKRVPAG TITEGTKIER
NCAYIAATGQ VKEPVYIHPH SSVFTPNPSK LPQFVVYQHI MRTTRAYMKM VTAIEPEWLA
GIGKNTPLCK YAPPLAEPAP FYHRELDEVQ CYAKAQYGIH QWALPAMRIP YPDQVTSDSK
DGLGGKYRWF AKFLLDGQVI TSLLPFSSAL KEPSHTLIRK KFDKKIQLLV AKLQQNRVAS
RRALVAKWSK EDGKLFLKAE LQSWIKDSHQ TAFSQAWGAL VKAAVQQERK ASSS
//
