ID D0NM04_PHYIT Unreviewed; 688 AA.
AC D0NM04;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Phosphatidylinositol kinase (PIK-F) {ECO:0000313|EMBL:EEY60701.1};
GN ORFNames=PITG_13441 {ECO:0000313|EMBL:EEY60701.1};
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677 {ECO:0000313|EMBL:EEY60701.1, ECO:0000313|Proteomes:UP000006643};
RN [1] {ECO:0000313|Proteomes:UP000006643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4 {ECO:0000313|Proteomes:UP000006643};
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type II PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00008941}.
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DR EMBL; DS028145; EEY60701.1; -; Genomic_DNA.
DR RefSeq; XP_002900074.1; XM_002900028.1.
DR AlphaFoldDB; D0NM04; -.
DR STRING; 403677.D0NM04; -.
DR EnsemblProtists; PITG_13441T0; PITG_13441T0; PITG_13441.
DR GeneID; 9478006; -.
DR KEGG; pif:PITG_13441; -.
DR VEuPathDB; FungiDB:PITG_13441; -.
DR eggNOG; KOG2381; Eukaryota.
DR HOGENOM; CLU_018753_0_0_1; -.
DR InParanoid; D0NM04; -.
DR OMA; CDWCWYN; -.
DR OrthoDB; 1699at2759; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd17039; Ubl_ubiquitin_like; 1.
DR InterPro; IPR044571; P4KG1-8.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45800; PHOSPHATIDYLINOSITOL 4-KINASE GAMMA; 1.
DR PANTHER; PTHR45800:SF11; PI3K_PI4K CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EEY60701.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006643};
KW Transferase {ECO:0000313|EMBL:EEY60701.1}.
FT DOMAIN 24..93
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT DOMAIN 184..472
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 688 AA; 76168 MW; AB5768E1380EC629 CRC64;
MQKDEAKMSR SLPGGWLESG HGAVVVFVKD FRDPLERRKK LMLRPWASIK DVKDQLQVVF
NVPSNAQKLF YQGRELKNAH NLQQCGIYQD NAVVDFVARR PQNLAMAYTH ECDDGRVSNV
SSGRNNGEGA ILKKSVPSRV NGKASQNLRP EQMPVVNIHP YGAHLLPVAL MKITHQALQG
LALGLAPVLA MDGTGGTYFF KDPSHRNVGC FKPQDEEPFG PNNPRGLVGQ LGQSGLRRGI
LSGEACEREL AAYVLDKDHF AGVPATSLVE SRHPVFNYTG SAGALHFKVG SLQEFVRHDD
VVSDLAPNQF STHQVHKIVV LDMRLLNTDR NDANILVRKR RSPATGHAEY ELIPIDHGYC
LPQFLEIGWC DWCWYNWPQL KKPLSAEDRA YVLSLSAEED ADRLAKRIPL RRGCRRNMII
ACMIVQKGVR ADLVLFDIAR IMCREDLDTP STLEQMCTEA FHQLQVVKQR KQNGVIFHHA
NLQPTITPVT KTSDPTIAED PMTTPIVIPA SPRAPFRNLR VSIDPPSLRG SLSIGCSPVA
SGAQSPPGFW ASYAPFSSDE EDEDTQECAK FSTSNAGGRH TFNASGKQRF SLHWDEMASH
ALSDAVKHAG NGFAGSIATP ASAPSNGHKM MIEQNASRSP TSSFMGAEDD KDEFEILNDA
LDDDVQDENI FLSILGRLLD ERIEAIKR
//
