ID D0PQY6_CAPHI Unreviewed; 77 AA.
AC D0PQY6;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 22-FEB-2023, entry version 42.
DE RecName: Full=Homeobox protein prophet of Pit-1 {ECO:0000256|ARBA:ARBA00019432};
DE AltName: Full=Pituitary-specific homeodomain factor {ECO:0000256|ARBA:ARBA00030888};
DE Flags: Fragment;
GN Name=PROP1 {ECO:0000313|EMBL:ABZ81937.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|EMBL:ABZ81937.1};
RN [1] {ECO:0000313|EMBL:ABZ81937.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19031010; DOI=10.1007/s11033-008-9418-x;
RA Lan X., Pan C., Zhang L., Zhao M., Zhang C., Lei C., Chen H.;
RT "A novel missense (A79V) mutation of goat PROP1 gene and its association
RT with production traits.";
RL Mol. Biol. Rep. 36:2069-2073(2009).
CC -!- FUNCTION: Possibly involved in the ontogenesis of pituitary
CC gonadotropes, as well as somatotropes, lactotropes and caudomedial
CC thyrotropes. {ECO:0000256|ARBA:ARBA00002030}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR EMBL; EU327393; ABZ81937.1; -; Genomic_DNA.
DR EMBL; EU327394; ABZ81938.1; -; Genomic_DNA.
DR AlphaFoldDB; D0PQY6; -.
DR SMR; D0PQY6; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0021983; P:pituitary gland development; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR042412; PROP1.
DR PANTHER; PTHR47409; HOMEOBOX PROTEIN PROPHET OF PIT-1; 1.
DR PANTHER; PTHR47409:SF1; HOMEOBOX PROTEIN PROPHET OF PIT-1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682}.
FT DOMAIN 30..77
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABZ81937.1"
FT NON_TER 77
FT /evidence="ECO:0000313|EMBL:ABZ81937.1"
SQ SEQUENCE 77 AA; 8762 MW; CE833BD202CADC9E CRC64;
MNTQPYRNLS GVRAGRPKLS LQGGQRGRPH SRRRHRTTFS PAQLEQLESA FGKNQYPDIW
ARESLAQDTG LSEARIQ
//
