ID   D0STX6_ACILW            Unreviewed;       820 AA.
AC   D0STX6;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=DNA internalization competence protein ComEC/Rec2-like protein {ECO:0000313|EMBL:EEY90980.1};
GN   ORFNames=HMPREF0017_00750 {ECO:0000313|EMBL:EEY90980.1};
OS   Acinetobacter lwoffii SH145.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter.
OX   NCBI_TaxID=575588 {ECO:0000313|EMBL:EEY90980.1, ECO:0000313|Proteomes:UP000018425};
RN   [1] {ECO:0000313|Proteomes:UP000018425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SH145 {ECO:0000313|Proteomes:UP000018425};
RX   PubMed=23144699; DOI=10.1371/journal.pone.0046984;
RA   Peleg A.Y., de Breij A., Adams M.D., Cerqueira G.M., Mocali S.,
RA   Galardini M., Nibbering P.H., Earl A.M., Ward D.V., Paterson D.L.,
RA   Seifert H., Dijkshoorn L.;
RT   "The success of Acinetobacter species; genetic, metabolic and virulence
RT   attributes.";
RL   PLoS ONE 7:E46984-E46984(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; GG705056; EEY90980.1; -; Genomic_DNA.
DR   RefSeq; WP_004279137.1; NZ_GG705056.1.
DR   AlphaFoldDB; D0STX6; -.
DR   eggNOG; COG0658; Bacteria.
DR   eggNOG; COG2333; Bacteria.
DR   HOGENOM; CLU_010363_3_1_6; -.
DR   Proteomes; UP000018425; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        51..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        310..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        359..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        451..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        479..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        509..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          564..761
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   820 AA;  93450 MW;  A299FC873C8C13F8 CRC64;
     MLQWLCIGWI LGLACMGKSF LSVQLSGTAV LIIALLWYLC CHKLKFILNT PLRSLLIAGS
     SLLLGLFLGH AYANLQLAER LSKREHEVAE KEIVVYIKEL NKLGDQNIQQ ALHVLNPDGT
     TIKWMGFLPV SDSVTSSLVN DETKQQTLEL GHYYLLQGQI RPNHSYATPG AFDAEKWALQ
     QNVMAGFRIK HIQELQPQQL YALGYGKYLR QQQNLGQRFL LWVEQQRLAL REFVARQPVQ
     QKGLLLALLS GDESLLDQAT EQQFQRFGMS HLLAISGPHV LIFAFIICGS LQYLISRYTP
     QIYLKWPRQY FLSLPFLLCV LLYCAFVGFE IPALRTLLIC VIVTFTLLLR QSVQPLKLLI
     LSAALLLLFD PFSILSAAFW LSYGACFVLL RIYQTIQQQP NQTIQTALQR LYFAMKVLVE
     SQWKIFLALF PLMMLFFKQV AWITPLSNLV AIPWIGLLIV PVDILAALLF FISEPLSSLL
     FQLNDIFIHM LLAFLNLLDR LFAPQLIPVA MNVWMIALCI LGLLIVFLPR GLVPKSWTAI
     ACVPLCIPQL NQHAFQLSVL DVGQGQAIFI RDGQHSMMID MGGYYNEEKF SIGRQVIMPF
     LSVQGVGELD RLILTHLDQD HSGAYFSIKD QLNIKQVSSN QMPETATSSS FQFCYEGQQW
     QWSEEINFKI LAPRQQQLNT PNFNKNDRSC VIYLQVKNAG PYQKFLLMGD AGWETEYQLL
     QNYPELKVDV LVLGHHGSQH SSAYQFLEVL RPKLTIASAG KFNRYGHPSQ LTQQRLKALN
     IPLLTTAEQG SVHFQQQGSK LVLSAERHEW QWLYRQPLSD
//