ID D0TSK2_9BACE Unreviewed; 424 AA.
AC D0TSK2;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=HMPREF0102_03046 {ECO:0000313|EMBL:EEZ03984.1};
OS Bacteroides sp. 2_1_22.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=469588 {ECO:0000313|EMBL:EEZ03984.1, ECO:0000313|Proteomes:UP000005775};
RN [1] {ECO:0000313|EMBL:EEZ03984.1, ECO:0000313|Proteomes:UP000005775}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2_1_22 {ECO:0000313|EMBL:EEZ03984.1,
RC ECO:0000313|Proteomes:UP000005775};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J., Yandava C.,
RA McDonald J., Allen-Vercoe E., Strauss J., Ambrose C., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Bacteroides sp. strain 2_1_22.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; GG705175; EEZ03984.1; -; Genomic_DNA.
DR RefSeq; WP_004314350.1; NZ_GG705175.1.
DR AlphaFoldDB; D0TSK2; -.
DR HOGENOM; CLU_000445_89_35_10; -.
DR Proteomes; UP000005775; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR PANTHER; PTHR45436:SF5; SENSOR HISTIDINE KINASE TRCS; 1.
DR PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEZ03984.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 222..424
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 424 AA; 49826 MW; 967E0619C489E9BB CRC64;
MKLIYYIILR ITLALTFILT VWAIFFYVTM IDEVNDEVDD ALEDYSETII IRALAGEELP
SKTNGSNNQY YMMEVSKEYA ESREDIQYKD SMVYIEEKEE TEPARILTTI FKDDEGRYHE
LTVSTPSIEK DDLRDAIQVW IIFLYVALLF CIIIISVWVF YRNMRPLYVL LHWLDGYQTG
KKNKPLSNET QITEFRKLNE AAIRYVERTE QMFEQQKQFI GNASHEIQTP LAICRNRLEM
LMEDDSLSEK QLEELMKTHQ TLEYITKLNK SLLLLTKIDN GQFTDTKQLE LNGLLKQYLQ
DYEEVYDYRN IEVTIDEQDI FNVTINESLA VALLTNLLKN AFVHNIDGGH IRITVTKNSI
TFRNSGVKNP LDKEHIFERF YQGTKKEGST GLGLAIADSI CRLQHLSIRY YFEQKEHCFE
ISRQ
//
