ID   D0ULD3_PERAM            Unreviewed;       283 AA.
AC   D0ULD3;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE            EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
DE   Flags: Fragment;
OS   Periplaneta americana (American cockroach) (Blatta americana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC   Blattinae; Periplaneta.
OX   NCBI_TaxID=6978 {ECO:0000313|EMBL:ACY43549.1};
RN   [1] {ECO:0000313|EMBL:ACY43549.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20147900; DOI=10.1038/nature08742;
RA   Regier J.C., Shultz J.W., Zwick A., Hussey A., Ball B., Wetzer R.,
RA   Martin J.W., Cunningham C.W.;
RT   "Arthropod relationships revealed by phylogenomic analysis of nuclear
RT   protein-coding sequences.";
RL   Nature 463:1079-1083(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC         [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC         COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:61930; EC=3.5.1.98;
CC         Evidence={ECO:0000256|ARBA:ARBA00001028};
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006457}.
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DR   EMBL; GQ885976; ACY43549.1; -; mRNA.
DR   AlphaFoldDB; D0ULD3; -.
DR   GO; GO:1902494; C:catalytic complex; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd09991; HDAC_classI; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PIRSF; PIRSF037913; His_deacetylse_1; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR037913-3};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT   DOMAIN          1..283
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   ACT_SITE        114
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
FT   BINDING         72
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037913-2"
FT   BINDING         122
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037913-2"
FT   BINDING         149
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037913-3"
FT   BINDING         151
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037913-3"
FT   BINDING         237
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037913-3"
FT   BINDING         276
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037913-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACY43549.1"
FT   NON_TER         283
FT                   /evidence="ECO:0000313|EMBL:ACY43549.1"
SQ   SEQUENCE   283 AA;  31980 MW;  BB0FAF47C3F00534 CRC64;
     HPMKPHRIRM THNLLLNYGL YRKMEIYRPH KATADEMTKF HSDDYVRFLR SIRPDNMSEY
     NKQMQRFNVG EDCPVFDGLY EFCQLSSGGS VAAAVKLNKQ ASEICINWGG GLHHAKKSEA
     SGFCYVNDIV LGILELLKYH QRVLYIDIDV HHGDGVEEAF YTTDRVMTVS FHKYGEYFPG
     TGDLRDIGAG KGKYYAVNIP LRDGMDDESY ESIFVPIISK VMETFQPSAV VLQCGADSLT
     GDRLGCFNLT VRGHGKCVEF VKKYGLPFLM VGGGGYTIRN VSR
//