ID D0UV44_HASV6 Unreviewed; 515 AA.
AC D0UV44;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 08-NOV-2023, entry version 43.
DE RecName: Full=Non-structural polyprotein 1AB {ECO:0000256|ARBA:ARBA00019743};
DE Flags: Fragment;
OS Human astrovirus-6 (HAstV-6).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae; Mamastrovirus; Mamastrovirus 1.
OX NCBI_TaxID=37130 {ECO:0000313|EMBL:ACX83560.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACX83560.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Rus-Nsc09-B4 {ECO:0000313|EMBL:ACX83560.1};
RX PubMed=22326537; DOI=10.1016/j.meegid.2012.01.019;
RA Babkin I.V., Tikunov A.Y., Zhirakovskaia E.V., Netesov S.V., Tikunova N.V.;
RT "High evolutionary rate of human astrovirus.";
RL Infect. Genet. Evol. 12:435-442(2012).
CC -!- FUNCTION: Contains the viral protease participating in the cleavage of
CC the polyprotein into functional products. It contains also the
CC activities necessary for replication of genomic RNA, as well as
CC transcription of subgenomic mRNA. {ECO:0000256|ARBA:ARBA00029407}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}.
CC -!- SIMILARITY: Belongs to the astroviridae polyprotein 1AB family.
CC {ECO:0000256|ARBA:ARBA00005873}.
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DR EMBL; GQ901902; ACX83560.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23172; ps-ssRNAv_Astroviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000313|EMBL:ACX83560.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 260..386
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACX83560.1"
SQ SEQUENCE 515 AA; 60294 MW; D0A72B8AA13D59AC CRC64;
GSKKLQRAPE DQGAQNYHSL DAWQVLLEPP RERRCVPTNF PLVGHLPINR PIYDDKKPRD
DLLGLLPEPT WHAFEEYGPT TWGPQAFIKS FDKFFYAEPI DFFSEYPQLC AFADWATYRE
FRYLEDTRVI HITATEKNTD STPAYPKMNY FDSEEEYLEA HGWAPYIREF TRVFRGEKPE
VLWYLFLKKE IIKEEKIRNS DIRQIVCADP IYTRIGACLE AHQNSLMKQH TETAVGQCGW
SPMEGGFKKT MQRLVNRGNK YFIEFDWTRY DGTIPPALFR HIKEIRWNFI NKDQREKYRH
VHEWYVDNLL NRHVLLPSGE VTVQTRGNPS GQFSTTMDNN MVNFWLQAFE FAYFNGPDKD
LWKTYDTVVY GDDRLSTTPS VPENYEERVI NMYRDIFGMW VKPGKVICRE SIVGLSFCGF
TVNADLEPVP TSPEKLMASL LKPYKILPDL ESLHGKLLCY QLLAAFMAED HPFKVYVEHC
LSRTAKQLRD SGLPARLTEE QLHRIWRGGP KKCDG
//
