ID D0V9N7_HHV2 Unreviewed; 376 AA.
AC D0V9N7;
DT 15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT 15-DEC-2009, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Thymidine kinase {ECO:0000313|EMBL:ACY01208.1};
GN Name=UL23 {ECO:0000313|EMBL:ACY01208.1};
GN ORFNames=HHV2gp25 {ECO:0000313|EMBL:ACY01208.1};
OS Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha2.
OX NCBI_TaxID=10310 {ECO:0000313|EMBL:ACY01208.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACY01208.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=20 {ECO:0000313|EMBL:ACY01208.1}, and 35
RC {ECO:0000313|EMBL:ACY01221.1};
RX PubMed=20702659; DOI=10.1128/JCM.01263-10;
RA Watson-Jones D., Wald A., Celum C., Lingappa J., Weiss H.A.,
RA Changalucha J., Baisley K., Tanton C., Hayes R.J., Marshak J.O.,
RA Green Gladden R.J., Koelle D.M.;
RT "Use of acyclovir for suppression of human immunodeficiency virus infection
RT is not associated with genotypic evidence of herpes simplex virus type 2
RT resistance to acyclovir: analysis of specimens from three phase III
RT trials.";
RL J. Clin. Microbiol. 48:3496-3503(2010).
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DR EMBL; GU057936; ACY01208.1; -; Genomic_DNA.
DR EMBL; GU057949; ACY01221.1; -; Genomic_DNA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006230; P:TMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04029; HSV_KITH; 1.
DR InterPro; IPR001889; Herpes_TK.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00693; Herpes_TK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACY01208.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACY01208.1}.
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 40503 MW; 77C2D5C996BA5399 CRC64;
MASHAGQQHA PAFGQAARAS GPTDGRAASR PSHRQGASEA RGDPELPTLL RVYIDGPHGV
GKTTTSAQLM EALGPRDDIV YVPEPMTYWQ VLGASETLTN IYDTQHRLDR GEISAGEAAV
VMTSAQITMS TPYAATDAVF APHIGGEAVG PQAPPPALTL VFDRHPIASL LCYPAARYLM
GSMTPQAVLA FVALMPPTAP GTNLVLGVLP EAEHADRLAR RQRPGERLDL AMLSAIRRVY
DLLANTVRYL QRGGRWREDW GRLTGVAAAT PRPDPEDGAG SLPRIEDTLF ALFRVPELLA
PNGDLYHIFA WVLDVLADRL LPMHLFVLDY DQSPVGCRDA LLRLTAGMIP TRVTTAGSIA
EIRDLARTFA REVGGV
//
