ID   D0VWT1_PLAKN            Unreviewed;       369 AA.
AC   D0VWT1;
DT   15-DEC-2009, integrated into UniProtKB/TrEMBL.
DT   15-DEC-2009, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Choline kinase {ECO:0000313|PDB:3C5I};
GN   ORFNames=PKH_134520 {ECO:0000313|PDB:3C5I};
OS   Plasmodium knowlesi.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5850 {ECO:0000313|PDB:3C5I};
RN   [1] {ECO:0000313|PDB:3C5I, ECO:0007829|PDB:3C5I}
RP   X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH CALCIUM.
RA   Wernimont A.K., Hills T., Lew J., Wasney G., Senisterra G., Kozieradzki I.,
RA   Cossar D., Vedadi M., Schapira M., Bochkarev A., Arrowsmith C.H.,
RA   Bountra C., Weigelt J., Edwards A.M., Hui R., Artz J.D., Xiao T.;
RT   "Crystal structure of Plasmodium knowlesi choline kinase, PKH_134520.";
RL   Submitted (JAN-2008) to the PDB data bank.
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}.
CC   -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC       {ECO:0000256|ARBA:ARBA00038211}.
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DR   PDB; 3C5I; X-ray; 2.20 A; A/B/C/D=2-369.
DR   PDBsum; 3C5I; -.
DR   AlphaFoldDB; D0VWT1; -.
DR   SMR; D0VWT1; -.
DR   VEuPathDB; PlasmoDB:PKA1H_130060800; -.
DR   VEuPathDB; PlasmoDB:PKNH_1356300; -.
DR   VEuPathDB; PlasmoDB:PKNOH_S05400100; -.
DR   EvolutionaryTrace; D0VWT1; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd14021; ChoK-like_euk; 1.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR   PANTHER; PTHR22603:SF93; RE24176P; 1.
DR   Pfam; PF01633; Choline_kinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000313|PDB:3C5I, ECO:0007829|PDB:3C5I};
KW   Calcium {ECO:0007829|PDB:3C5I}; Metal-binding {ECO:0007829|PDB:3C5I}.
FT   BINDING         221
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0007829|PDB:3C5I"
FT   BINDING         223
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:3C5I"
FT   BINDING         235
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:3C5I"
FT   BINDING         254
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0007829|PDB:3C5I"
FT   BINDING         257
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0007829|PDB:3C5I"
SQ   SEQUENCE   369 AA;  43783 MW;  E68DB4AE3C7E2651 CRC64;
     GPLCAQEFSD LTDPLYIKKI CLEKVPEWNH FTEDNLRVKQ ILSGLTNQLF EVGLKEETAN
     NYNSIRTRVL FRIYGKHVDE LYNTISEFEV YKTMSKYKIA PQLLNTFNGG RIEEWLYGDP
     LRIDDLKNPT ILIGIANVLG KFHTLSRKRH LPEHWDRTPC IFKMMEKWKN QLFKYKNIEK
     YNCDIHKYIK ESDKFIKFMK VYSKSDNLAN TIVFCHNDLQ ENNIINTNKC LRLIDFEYSG
     FNFLATDIAN FFIETSIDYS VSSYPFFEID KKKYISYENR KLFITAYLSN YLDKSLVVPT
     PKLIDEILEA VEVQALGAHL LWGFWSIIRG YQTKSYNEFD FFLYAEQRLK MYDDQKEYLI
     SNNIIKGYD
//