ID D0W9U5_NEILA Unreviewed; 735 AA.
AC D0W9U5;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=uvrD {ECO:0000313|EMBL:EEZ75609.1};
GN ORFNames=NEILACOT_04308 {ECO:0000313|EMBL:EEZ75609.1};
OS Neisseria lactamica ATCC 23970.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=546265 {ECO:0000313|EMBL:EEZ75609.1, ECO:0000313|Proteomes:UP000003843};
RN [1] {ECO:0000313|EMBL:EEZ75609.1, ECO:0000313|Proteomes:UP000003843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23970 {ECO:0000313|EMBL:EEZ75609.1,
RC ECO:0000313|Proteomes:UP000003843};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEZ75609.1}.
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DR EMBL; ACEQ02000014; EEZ75609.1; -; Genomic_DNA.
DR RefSeq; WP_003709242.1; NZ_KN046803.1.
DR AlphaFoldDB; D0W9U5; -.
DR PATRIC; fig|546265.8.peg.1670; -.
DR Proteomes; UP000003843; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR005753; DNA_helicase_ATP-dep_UvrD.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01075; uvrD; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 12..289
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 290..569
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 735 AA; 82337 MW; 25AD25351CF37E71 CRC64;
MFPDQSAPNL LQGLNPEQLS AVTWPPQSAL VLAGAGSGKT RVLTTRIAWL LQTGQASVHS
IMAVTFTNKA AKEMQTRLGA MIPVNVRAMW LGTFHGLCHR FLRLHHRDAG LPSSFQILDS
GDQLSLIKRL LKSLNIAEEI IAPRSLQGFI NAQKESGLRA SVLSAPDPHT RRMIECYAEY
DKICQREGVV DFAELMLRSY EMLQSNEMLR QHYQNRFNHI LVDEFQDTNK LQYAWLKLIA
GNHAAVFAVG DDDQSIYRFR GANVGNMTAL MEEFHIDAPV KLEQNYRSVG NILAAANAVI
ENNDERLGKN LRTDAEAGDK IRYYSAFTDL EEAQFIVDET KALEREGRNL DEIAVLYRSN
AQSRVIEQSL FRSGIPYKIY GGLRFYERQE IKHALAYLRL AVNPDDDNAL LRVINFPPRG
IGARTVENLQ TASQEQGVSL WQAACNAGAK AAKVAAFVRL IEAFRNQVGQ MPLPEIIVGI
LKDSGLTEYY KTQKGDNQDR LDNLDELVNA AIEFKPEDSN FEILPDNISD DPAFPILAFL
SNAALESGEN QAGAGEKAVQ LMTVHAAKGL EFNAVFLTGM EEGRFPSEMS LAERGGLEEE
RRLMYVAITR ARKRLYITMA QQRMLHGQTQ FGIVSRFVEE IPPEVLHYLS VKKPAYDRYG
NTRQTAAPKD KIIDDYKQPQ TYAGFRIGQN VRHAKFGTGV IIDAVDQGES ARLTINFGKQ
GVKELDTKFA KLEEM
//
