ID   D1A512_THECD            Unreviewed;       308 AA.
AC   D1A512;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Transcriptional regulator, AsnC family {ECO:0000313|EMBL:ACY98181.1};
GN   OrderedLocusNames=Tcur_2627 {ECO:0000313|EMBL:ACY98181.1};
OS   Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC
OS   9072 / NBRC 15933 / NCIMB 10081 / Henssen B9).
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Thermomonospora.
OX   NCBI_TaxID=471852 {ECO:0000313|EMBL:ACY98181.1, ECO:0000313|Proteomes:UP000001918};
RN   [1] {ECO:0000313|EMBL:ACY98181.1, ECO:0000313|Proteomes:UP000001918}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 /
RC   NCIMB 10081 / Henssen B9 {ECO:0000313|Proteomes:UP000001918};
RX   PubMed=21475583; DOI=10.4056/sigs.1453580;
RA   Chertkov O., Sikorski J., Nolan M., Lapidus A., Lucas S., Del Rio T.G.,
RA   Tice H., Cheng J.F., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA   Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A.,
RA   Palaniappan K., Djao O.D., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Brettin T., Han C., Detter J.C., Rohde M., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT   "Complete genome sequence of Thermomonospora curvata type strain (B9).";
RL   Stand. Genomic Sci. 1:13-22(2011).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001738; ACY98181.1; -; Genomic_DNA.
DR   RefSeq; WP_012852965.1; NC_013510.1.
DR   AlphaFoldDB; D1A512; -.
DR   STRING; 471852.Tcur_2627; -.
DR   KEGG; tcu:Tcur_2627; -.
DR   eggNOG; COG1522; Bacteria.
DR   HOGENOM; CLU_061382_0_0_11; -.
DR   OrthoDB; 3526090at2; -.
DR   Proteomes; UP000001918; Chromosome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 3.30.70.920; -; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30154; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR   PANTHER; PTHR30154:SF34; TRANSCRIPTIONAL REGULATOR AZLB; 1.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   Pfam; PF13404; HTH_AsnC-type; 2.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 2.
DR   SUPFAM; SSF54909; Dimeric alpha+beta barrel; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR   PROSITE; PS50956; HTH_ASNC_2; 2.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001918};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          2..62
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50956"
FT   DOMAIN          152..212
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50956"
SQ   SEQUENCE   308 AA;  32636 MW;  48CE15FC544E97DE CRC64;
     MLDAVDTVLV RELQRDGRAT FQALADRVGL SRTAVRARVQ HLLETQVVRV VGIVHSAVVG
     TQAVGHVSIT VDGSARQAAE SIAARPCVSF AALTAGPCDL VAQVRTRDDE ALAAEVDQLR
     AIAGVRSAEV FRSVATVRDA YSVVRELGDI ALDDIDWRLL QELQRDGRAP YTRLAQIIGL
     SQAATRARVV RLMRSGVIQV TGLADPLALG AAELGGFGVV VDTGGVRKVA EAVAAQPGVR
     YVAAGFGRYD IVGLAEASSR EELVNILDAI RAVPGATVRD SWHHLEVIKE SYAAELPDKP
     QEAGRAAG
//