ID D1AC35_THECD Unreviewed; 551 AA.
AC D1AC35;
DT 19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT 19-JAN-2010, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:ACY97301.1};
GN OrderedLocusNames=Tcur_1727 {ECO:0000313|EMBL:ACY97301.1};
OS Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / KCTC
OS 9072 / NBRC 15933 / NCIMB 10081 / Henssen B9).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=471852 {ECO:0000313|EMBL:ACY97301.1, ECO:0000313|Proteomes:UP000001918};
RN [1] {ECO:0000313|EMBL:ACY97301.1, ECO:0000313|Proteomes:UP000001918}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19995 / DSM 43183 / JCM 3096 / KCTC 9072 / NBRC 15933 /
RC NCIMB 10081 / Henssen B9 {ECO:0000313|Proteomes:UP000001918};
RX PubMed=21475583; DOI=10.4056/sigs.1453580;
RA Chertkov O., Sikorski J., Nolan M., Lapidus A., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Goodwin L., Pitluck S., Liolios K., Ivanova N.,
RA Mavromatis K., Mikhailova N., Ovchinnikova G., Pati A., Chen A.,
RA Palaniappan K., Djao O.D., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Brettin T., Han C., Detter J.C., Rohde M., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Thermomonospora curvata type strain (B9).";
RL Stand. Genomic Sci. 1:13-22(2011).
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DR EMBL; CP001738; ACY97301.1; -; Genomic_DNA.
DR AlphaFoldDB; D1AC35; -.
DR STRING; 471852.Tcur_1727; -.
DR KEGG; tcu:Tcur_1727; -.
DR eggNOG; COG0318; Bacteria.
DR HOGENOM; CLU_000022_59_7_11; -.
DR Proteomes; UP000001918; Chromosome.
DR GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR CDD; cd05936; FC-FACS_FadD_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:ACY97301.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001918}.
FT DOMAIN 17..410
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 460..535
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 551 AA; 61281 MW; 3A0767BFD9FEF789 CRC64;
MPAEVDVPPV PVPHLLDETA ARLPRRTAYI FYGRRLAYRQ VRNLVDRFAA GLQTLGVRPG
DRVSLVLPNC PQMAIVFFAV LRLGAVAVPH NPLYTAEEMG RQLADCGSRV AVVLDRSYAT
VRSVRHSVPL EHVVVTSLTE YLPWPQRLAL RLPLASMRRK RAALTAEVPP DPGVIGFGEL
LRRSRQPARQ TWLVPDRHPA AIQYTGGTEG RPKGVTLTHR NLVANAYQKQ TWDLESRDGR
EVTLAVLPLF HSFGMTACLI APVVRAETVV LLPRYDAGQV IRALRRYRPT IFPGVPTLYE
QVLDTPGVER RDLASVRLWL SGASSLTART IERFHRMGLR GLVQAYGLTE ASPAVSSNPG
DGRARNETVG LPLPSTDVVI VDVDDPTRVL PPGRPGEVVV RGPQVFAGYW NRPEETARVL
SNGWLRTGDI GVMSPDGFLT ILDRKQDLIK VSGFSVYPSE VEEVLYRHPA VIECAVVGVP
DERRGEKVVA CVVEHPAYPF SADELRRHCE KYLSHYKVPE EFLPRSALPR SGIGKVMRRV
LREECLLEVT H
//
