ID   D1J6X9_STRPU            Unreviewed;       840 AA.
AC   D1J6X9;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   SubName: Full=Two-pore channel 3 {ECO:0000313|EMBL:CBI63265.1};
GN   Name=tpcn3 {ECO:0000313|EMBL:CBI63265.1};
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668 {ECO:0000313|EMBL:CBI63265.1};
RN   [1] {ECO:0000313|EMBL:CBI63265.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Brailoiu E., Hooper R., Cai X., Brailoiu G.C., Keebler M.V., Dun N.J.,
RA   Marchant J.S., Patel S.;
RT   "An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic
RT   Acid Adenine Dinucleotide Phosphatedependent Calcium Release from Acidic
RT   Organelles.";
RL   J. Biol. Chem. 285:2897-2901(2010).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FN598568; CBI63265.1; -; mRNA.
DR   AlphaFoldDB; D1J6X9; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 2.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR46726; TWO PORE CHANNEL 3; 1.
DR   PANTHER; PTHR46726:SF1; TWO PORE CHANNEL 3; 1.
DR   Pfam; PF00520; Ion_trans; 2.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        125..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        160..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        233..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        331..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        480..500
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        506..525
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        532..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        597..619
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        701..723
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          131..360
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          478..728
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          756..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          805..840
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        805..826
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   840 AA;  97844 MW;  2A87FFD919065436 CRC64;
     MEGPKDYVDS YMPKSKSKSS NTKISDNTKT SDNKLDNTTS LDKTTFSEPS SPVTSSSLSR
     SDKELTPVIE FIEMEVNANG RAKAFSVSLH PIKALDLFLA ATYIKDAKYG RKFKFKTSEK
     HLRYYHLYNM PIFSWVLYLF MLLNLSLAIF EEPAVGNLHI PYWASMLLET SCLVYFTLRL
     LHSHYCAAGR WFRDMKNVAS ITVIILTVVD MVMFTMMYEL GAKDKAVRWS RPLRPVLMVT
     FAEMKLVRLA FSNIRKTLLE ILNVLILLFL VIALFALLGR ELFGNDNLKK VDEVSPYFTD
     FWEIWWDLYV LVTTANSPDI MMPAYDFNPW YMLYFITYIF ICLYIFMSIF LAVIYKNYRK
     HLKNEVQKSV FNKRRKLASA WDILKEWHGG RFLLSWGRWK EMMGMVAPKL NRAHVRLLWR
     VLDQDGVNFI NKRTFMKVVD ILNVPIVQVD KQKSFSERRC PTCYNSKASL FMRKVINHRY
     FTYVFDLLII INAFFVGFKL DEGEPYFLAL FSVEIALKMY ALGFYKFFRS FWNVFDFLVI
     GAAVVITIIE AILDSNETET TLDILLILRV LRLVRIINNI ERFHVIVATV MNIGPSIVTF
     GAIIFVVFYI FAVIGMELYG GKVNYYGYEI DGADLTEDEL YCGNPLLRGS DFYRDHYCNN
     NFNNILKAFI LLIELMVVNQ WHVISEGYVI VTNKASRLYF LFFHISVVIV IINIFIAFIL
     EVFMVEYSLS KTEYESALEK VVEDLGLSDK VDDLEEASRR RKKPDRKELV KEMEQEHPEN
     PDDNIKFRLG KRRKAMQVTL QNMFEGELDD EDIGPEEIDD VDDMPETDIT PFPLSVDNIA
//