UniProt: D1M715

Database: UniProt
Entry: D1M715_HUMAN

LinkDB:  D1M715_HUMAN 
Original site:  D1M715_HUMAN

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Ontology (3)   
   GO (3)   
DNA sequence (87)   
   EMBL (87)   
Protein domain (4)   
   InterPro (3)   
   Pfam (1)   
Literature (2)   
   PubMed (2)   
All databases (96)   

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ID   D1M715_HUMAN            Unreviewed;        81 AA.
AC   D1M715;
DT   19-JAN-2010, integrated into UniProtKB/TrEMBL.
DT   19-JAN-2010, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Gamma-aminobutyric acid A receptor beta 2 {ECO:0000313|EMBL:ACY71653.1};
DE   Flags: Fragment;
GN   Name=GABRB2 {ECO:0000313|EMBL:ACY71653.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACY71653.1};
RN   [1] {ECO:0000313|EMBL:ACY71653.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17520021; DOI=10.1371/journal.pone.0000462;
RA   Lo W.S., Xu Z., Yu Z., Pun F.W., Ng S.K., Chen J., Tong K.L., Zhao C.,
RA   Xu X., Tsang S.Y., Harano M., Stober G., Nimgaonkar V.L., Xue H.;
RT   "Positive selection within the Schizophrenia-associated GABA(A) receptor
RT   beta2 gene.";
RL   PLoS ONE 2:E462-E462(2007).
RN   [2] {ECO:0000313|EMBL:ACY71653.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20221451; DOI=10.1371/journal.pone.0009547;
RA   Ng S.K., Lo W.S., Pun F.W., Zhao C., Yu Z., Chen J., Tong K.L., Xu Z.,
RA   Tsang S.Y., Yang Q., Yu W., Nimgaonkar V., Stober G., Harano M., Xue H.;
RT   "A recombination hotspot in a schizophrenia-associated region of GABRB2.";
RL   PLoS ONE 5:E9547-E9547(2010).
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DR   EMBL; GU117779; ACY71653.1; -; Genomic_DNA.
DR   EMBL; GU117780; ACY71654.1; -; Genomic_DNA.
DR   EMBL; GU117781; ACY71655.1; -; Genomic_DNA.
DR   EMBL; GU117782; ACY71656.1; -; Genomic_DNA.
DR   EMBL; GU117783; ACY71657.1; -; Genomic_DNA.
DR   EMBL; GU117784; ACY71658.1; -; Genomic_DNA.
DR   EMBL; GU117785; ACY71659.1; -; Genomic_DNA.
DR   EMBL; GU117786; ACY71660.1; -; Genomic_DNA.
DR   EMBL; GU117787; ACY71661.1; -; Genomic_DNA.
DR   EMBL; GU117788; ACY71662.1; -; Genomic_DNA.
DR   EMBL; GU117789; ACY71663.1; -; Genomic_DNA.
DR   EMBL; GU117790; ACY71664.1; -; Genomic_DNA.
DR   EMBL; GU117791; ACY71665.1; -; Genomic_DNA.
DR   EMBL; GU117792; ACY71666.1; -; Genomic_DNA.
DR   EMBL; GU117793; ACY71667.1; -; Genomic_DNA.
DR   EMBL; GU117794; ACY71668.1; -; Genomic_DNA.
DR   EMBL; GU117795; ACY71669.1; -; Genomic_DNA.
DR   EMBL; GU117796; ACY71670.1; -; Genomic_DNA.
DR   EMBL; GU117797; ACY71671.1; -; Genomic_DNA.
DR   EMBL; GU117798; ACY71672.1; -; Genomic_DNA.
DR   EMBL; GU117799; ACY71673.1; -; Genomic_DNA.
DR   EMBL; GU117800; ACY71674.1; -; Genomic_DNA.
DR   EMBL; GU117801; ACY71675.1; -; Genomic_DNA.
DR   EMBL; GU117802; ACY71676.1; -; Genomic_DNA.
DR   EMBL; GU117803; ACY71677.1; -; Genomic_DNA.
DR   EMBL; GU117804; ACY71678.1; -; Genomic_DNA.
DR   EMBL; GU117805; ACY71679.1; -; Genomic_DNA.
DR   EMBL; GU117806; ACY71680.1; -; Genomic_DNA.
DR   EMBL; GU117807; ACY71681.1; -; Genomic_DNA.
DR   EMBL; GU117809; ACY71683.1; -; Genomic_DNA.
DR   EMBL; GU117810; ACY71684.1; -; Genomic_DNA.
DR   EMBL; GU117811; ACY71685.1; -; Genomic_DNA.
DR   EMBL; GU117812; ACY71686.1; -; Genomic_DNA.
DR   EMBL; GU117813; ACY71687.1; -; Genomic_DNA.
DR   EMBL; GU117814; ACY71688.1; -; Genomic_DNA.
DR   EMBL; GU117816; ACY71690.1; -; Genomic_DNA.
DR   EMBL; GU117817; ACY71691.1; -; Genomic_DNA.
DR   EMBL; GU117818; ACY71692.1; -; Genomic_DNA.
DR   EMBL; GU117819; ACY71693.1; -; Genomic_DNA.
DR   EMBL; GU117820; ACY71694.1; -; Genomic_DNA.
DR   EMBL; GU117821; ACY71695.1; -; Genomic_DNA.
DR   EMBL; GU117822; ACY71696.1; -; Genomic_DNA.
DR   EMBL; GU117823; ACY71697.1; -; Genomic_DNA.
DR   EMBL; GU117824; ACY71698.1; -; Genomic_DNA.
DR   EMBL; GU117825; ACY71699.1; -; Genomic_DNA.
DR   EMBL; GU117826; ACY71700.1; -; Genomic_DNA.
DR   EMBL; GU117827; ACY71701.1; -; Genomic_DNA.
DR   EMBL; GU117828; ACY71702.1; -; Genomic_DNA.
DR   EMBL; GU117829; ACY71703.1; -; Genomic_DNA.
DR   EMBL; GU117830; ACY71704.1; -; Genomic_DNA.
DR   EMBL; GU117831; ACY71705.1; -; Genomic_DNA.
DR   EMBL; GU117832; ACY71706.1; -; Genomic_DNA.
DR   EMBL; GU117833; ACY71707.1; -; Genomic_DNA.
DR   EMBL; GU117834; ACY71708.1; -; Genomic_DNA.
DR   EMBL; GU117835; ACY71709.1; -; Genomic_DNA.
DR   EMBL; GU117836; ACY71710.1; -; Genomic_DNA.
DR   EMBL; GU117837; ACY71711.1; -; Genomic_DNA.
DR   EMBL; GU117838; ACY71712.1; -; Genomic_DNA.
DR   EMBL; GU117839; ACY71713.1; -; Genomic_DNA.
DR   EMBL; GU117840; ACY71714.1; -; Genomic_DNA.
DR   EMBL; GU117841; ACY71715.1; -; Genomic_DNA.
DR   EMBL; GU117842; ACY71716.1; -; Genomic_DNA.
DR   EMBL; GU117843; ACY71717.1; -; Genomic_DNA.
DR   EMBL; GU117844; ACY71718.1; -; Genomic_DNA.
DR   EMBL; GU117845; ACY71719.1; -; Genomic_DNA.
DR   EMBL; GU117846; ACY71720.1; -; Genomic_DNA.
DR   EMBL; GU117847; ACY71721.1; -; Genomic_DNA.
DR   EMBL; GU117848; ACY71722.1; -; Genomic_DNA.
DR   EMBL; GU117849; ACY71723.1; -; Genomic_DNA.
DR   EMBL; GU117850; ACY71724.1; -; Genomic_DNA.
DR   EMBL; GU117851; ACY71725.1; -; Genomic_DNA.
DR   EMBL; GU117852; ACY71726.1; -; Genomic_DNA.
DR   EMBL; GU117853; ACY71727.1; -; Genomic_DNA.
DR   EMBL; GU117854; ACY71728.1; -; Genomic_DNA.
DR   EMBL; GU117855; ACY71729.1; -; Genomic_DNA.
DR   EMBL; GU117856; ACY71730.1; -; Genomic_DNA.
DR   EMBL; GU117857; ACY71731.1; -; Genomic_DNA.
DR   EMBL; GU117858; ACY71732.1; -; Genomic_DNA.
DR   EMBL; GU117859; ACY71733.1; -; Genomic_DNA.
DR   EMBL; GU117860; ACY71734.1; -; Genomic_DNA.
DR   EMBL; GU117861; ACY71735.1; -; Genomic_DNA.
DR   EMBL; GU117862; ACY71736.1; -; Genomic_DNA.
DR   EMBL; GU117863; ACY71737.1; -; Genomic_DNA.
DR   EMBL; GU117864; ACY71738.1; -; Genomic_DNA.
DR   EMBL; GU117866; ACY71740.1; -; Genomic_DNA.
DR   EMBL; GU117867; ACY71741.1; -; Genomic_DNA.
DR   EMBL; GU117868; ACY71742.1; -; Genomic_DNA.
DR   AlphaFoldDB; D1M715; -.
DR   PeptideAtlas; D1M715; -.
DR   ChiTaRS; GABRB2; human.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   Gene3D; 6.10.250.2810; -; 1.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   PANTHER; PTHR18945:SF221; GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-2; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:ACY71653.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..77
FT                   /note="Neurotransmitter-gated ion-channel transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF02932"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACY71653.1"
FT   NON_TER         81
FT                   /evidence="ECO:0000313|EMBL:ACY71653.1"
SQ   SEQUENCE   81 AA;  9290 MW;  2524DEFE3DBC9FB1 CRC64;
     ITTVLTMTTI NTHLRETLPK IPYVKAIDMY LMGCFVFVFM ALLEYALVNY IFFGRGPQRQ
     KKAAEKAASA NNEKMRLDVN K
//

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