ID D1VTU8_9FIRM Unreviewed; 977 AA.
AC D1VTU8;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HMPREF0628_0832 {ECO:0000313|EMBL:EFA90061.1};
OS Peptoniphilus lacrimalis 315-B.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC Peptoniphilus.
OX NCBI_TaxID=596330 {ECO:0000313|EMBL:EFA90061.1, ECO:0000313|Proteomes:UP000005711};
RN [1] {ECO:0000313|EMBL:EFA90061.1, ECO:0000313|Proteomes:UP000005711}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=315-B {ECO:0000313|EMBL:EFA90061.1,
RC ECO:0000313|Proteomes:UP000005711};
RA Durkin A.S., Madupu R., Torralba M., Methe B., Sutton G., Strausberg R.L.,
RA Nelson K.E.;
RT "Genome Sequence of Peptoniphilus lacrimalis 315-B.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFA90061.1}.
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DR EMBL; ADDO01000043; EFA90061.1; -; Genomic_DNA.
DR RefSeq; WP_004824921.1; NZ_ADDO01000043.1.
DR AlphaFoldDB; D1VTU8; -.
DR eggNOG; COG1074; Bacteria.
DR Proteomes; UP000005711; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000005711}.
FT DOMAIN 1..393
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 393..637
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 977 AA; 115272 MW; 3CC4704CE54BCE89 CRC64;
MVLNEIQQKA STILDKNISL ISGAGTGKTG VLTQRFINII KAQNGKFDNI LALTFTDKAT
EEMNNRIYHE LAKTSYDFNI DKLNIMTIHS FCKDLILSYN RYLHINSNFD LDNDFFCQIL
LKESIKKILS TYNNEDYLSF LLDLNFSIVP RDVEDIFFDL YNRLRNKNIS LDDLKNASFV
NFESCEDKNS LKNNLLTLGK NKSLKTLNKF INSSIFSEIF DKENLDSSDL YTIKENLGQS
KNFEDELNSV KEQISNLLLA LDDSNYKYYE IIIEILEKIH KLYTKEKRQR GLLDFDDLLI
YGNELVQNKD VSDKLNKKFT YILIDEFQDV NILQNNIICG LNAKNIFIVG DPQQAIYGFR
GSFIGIFDNF YKLFRDKDKE ILTLNMNKNY RTDAFIISDI NTLFNNIFTD YQGLVANNKA
SRKIEKYTVD DEDDYLKLIK YLLSENDSKD IGILARTNGE LEKLETYLKQ NNIDVNRGKI
NLKQTQVIKF ILSFLRSIFN KNDFTSFMDY ISSPFCDLSF NSLVTVLLKG YRSIDEVCHG
DISDSNLARA IDVYIKIKKI KNVSSLDYLI KKCIDEFRIF KLNRNDWDYI LILYEKSIEF
KEKGLSSFRV FERYIESVEV NDKSQGVNLL TIHKSKGLEF KTVVLINMSK PLSNKTSQKI
TFNKKFGLAI DSQRSNGKFD LINNEQKDIN FEEERRVLYV AMTRARDRLI ICSEKKQSPA
SYMSILNAPD KFFKEVNIDE EEYQVKVNED TRKLINLNEA FKYRYRQNYS ITDFLNYDYD
EDAYLMKFFF NRDTKKLQGN TYYIDPKVRG NMLHFFAEHY NEEKIDDYIE FLFKIFKEDI
NGNKFNEIRE LIVNYLNLRD KEILYKELEF FYDFNGHIVR GFIDQVVYDE AIYIVDLKTS
DLSEEELVKN YKWQLVFYSK VFKNIYKKEV KGAFIYSLKH CKKVPVEIND KIINELDEKF
LKFIEQSRKI NFYKIFS
//
