ID D1YYL2_METPS Unreviewed; 289 AA.
AC D1YYL2;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Diadenylate cyclase {ECO:0000256|HAMAP-Rule:MF_00840};
DE Short=DAC {ECO:0000256|HAMAP-Rule:MF_00840};
DE EC=2.7.7.85 {ECO:0000256|HAMAP-Rule:MF_00840};
DE AltName: Full=Cyclic-di-AMP synthase {ECO:0000256|HAMAP-Rule:MF_00840};
DE Short=c-di-AMP synthase {ECO:0000256|HAMAP-Rule:MF_00840};
GN Name=dacZ {ECO:0000256|HAMAP-Rule:MF_00840};
GN OrderedLocusNames=MCP_1462 {ECO:0000313|EMBL:BAI61534.1};
OS Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS SANAE).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanocellales; Methanocellaceae; Methanocella.
OX NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI61534.1, ECO:0000313|Proteomes:UP000001882};
RN [1] {ECO:0000313|Proteomes:UP000001882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC {ECO:0000313|Proteomes:UP000001882};
RX PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA Mori K., Fujita N., Imachi H., Takai K.;
RT "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT paludicola, the first cultivated representative of the order
RT Methanocellales.";
RL PLoS ONE 6:E22898-E22898(2011).
CC -!- FUNCTION: Diadenylate cyclase that catalyzes the condensation of 2 ATP
CC molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger
CC for intracellular signal transduction involved in the control of
CC important regulatory processes such as osmoregulation.
CC {ECO:0000256|HAMAP-Rule:MF_00840}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=2.7.7.85;
CC Evidence={ECO:0000256|ARBA:ARBA00000877, ECO:0000256|HAMAP-
CC Rule:MF_00840};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00840};
CC -!- SIMILARITY: Belongs to the adenylate cyclase family. DacZ subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_00840}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP011532; BAI61534.1; -; Genomic_DNA.
DR AlphaFoldDB; D1YYL2; -.
DR STRING; 304371.MCP_1462; -.
DR KEGG; mpd:MCP_1462; -.
DR PATRIC; fig|304371.9.peg.1499; -.
DR eggNOG; arCOG04453; Archaea.
DR InParanoid; D1YYL2; -.
DR OrthoDB; 85944at2157; -.
DR Proteomes; UP000001882; Chromosome.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0106408; F:diadenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019932; P:second-messenger-mediated signaling; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1700.10; DNA integrity scanning protein, DisA, N-terminal domain; 1.
DR HAMAP; MF_00840; DacZ; 1.
DR InterPro; IPR014499; DAC_DacZ.
DR InterPro; IPR048546; DacZ_A.
DR InterPro; IPR036888; DNA_integrity_DisA_N_sf.
DR InterPro; IPR003390; DNA_integrity_scan_DisA_N.
DR PANTHER; PTHR34185; DIADENYLATE CYCLASE; 1.
DR PANTHER; PTHR34185:SF1; DIADENYLATE CYCLASE; 1.
DR Pfam; PF02457; DAC; 1.
DR Pfam; PF21754; DacZ_A; 1.
DR SUPFAM; SSF143597; YojJ-like; 1.
DR PROSITE; PS51794; DAC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00840}; Manganese {ECO:0000256|HAMAP-Rule:MF_00840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00840};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00840};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00840}.
FT DOMAIN 129..284
FT /note="DAC"
FT /evidence="ECO:0000259|PROSITE:PS51794"
SQ SEQUENCE 289 AA; 31041 MW; 6B04467410FC11F5 CRC64;
MSIRDEVVAS ALGLARDLDA GSIILISPEA SAIRKELDTD IPIIIARILG GRGDGDDIFV
DIMSKLPKNI GKSSLFLKVS RIELMSEAVE VAYIKGMIPN KVTVGIVSIG DINSIVVMDI
NDIPLIKKMA ELASSMNYTV LKAVLNLAMD IGREGREGKK VGTAFVVGDT EKVLGMSHQI
VLNPYEGHRK KDRDVKDENS WETVKEFAQL DGMFIVDEAG YIVAAGRYLD VNAKNVELPP
GLGGRHLAAA AISKCTKAIA ITVSESSGVV SVYKGGRDVF TIDPRVSIT
//
