ID   D2AC37_SHIF2            Unreviewed;       464 AA.
AC   D2AC37;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Putative transport protein {ECO:0000313|EMBL:ADA73355.1};
GN   Name=rutG {ECO:0000313|EMBL:ADA73355.1};
GN   OrderedLocusNames=SFxv_1095 {ECO:0000313|EMBL:ADA73355.1};
OS   Shigella flexneri serotype X (strain 2002017).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=591020 {ECO:0000313|EMBL:ADA73355.1, ECO:0000313|Proteomes:UP000001884};
RN   [1] {ECO:0000313|EMBL:ADA73355.1, ECO:0000313|Proteomes:UP000001884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2002017 {ECO:0000313|EMBL:ADA73355.1,
RC   ECO:0000313|Proteomes:UP000001884};
RX   PubMed=19955273; DOI=10.1128/JCM.00614-09;
RA   Ye C., Lan R., Xia S., Zhang J., Sun Q., Zhang S., Jing H., Wang L., Li Z.,
RA   Zhou Z., Zhao A., Cui Z., Cao J., Jin D., Huang L., Wang Y., Luo X.,
RA   Bai X., Wang Y., Wang P., Xu Q., Xu J.;
RT   "Emergence of a new multidrug-resistant serotype X variant in an epidemic
RT   clone of Shigella flexneri.";
RL   J. Clin. Microbiol. 48:419-426(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR   EMBL; CP001383; ADA73355.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2AC37; -.
DR   KEGG; sfe:SFxv_1095; -.
DR   PATRIC; fig|591020.3.peg.1169; -.
DR   HOGENOM; CLU_017959_1_1_6; -.
DR   Proteomes; UP000001884; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0015218; F:pyrimidine nucleotide transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR019918; Pyrimidine_permease_RutG_pred.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   NCBIfam; TIGR03616; RutG; 1.
DR   PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        55..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        195..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        270..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        307..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        341..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        425..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   464 AA;  48142 MW;  664C7803AF3EE025 CRC64;
     MVRSQLSRAD APCLLTSLRR QLMAMFGFPH WQLKSTSTES GVVAPDERLP FAQTAVMGVQ
     HAVAMFGATV LMPILMGLDP NLSILMSGIG TLLFFFITGG RVPSYLGSSA AFVGVVIAAT
     GFNGQGINPN ISIALGGIIA CGLVYTVIGL VVMKIGTRWI ERLMPPVVTG AVVMAIGLNL
     APIAVKSVSA SAFDSWMAVM TVLCIGLVAV FTRGMIQRLL ILVGLIVACL LYGVMTNVLG
     LGKAVDFTLV SYAAWFGLPH FSTPGFNGQA MMLIAPVAVI LVAENLGHLK AVAGMTGRNM
     DPYMGRAFVG DGLATMLSGS VGGSGVTTYA ENIGVMAVTK VYSTLVFVAA AVIAMLLGFS
     PKFGALIHTI PAAVIGGASI VVFGLIAVAG ARIWVQNRVD LSQNANLIMV AVTFVLGAGD
     FALTLGGFTL GGIGTATFGA ILLNALLSRR LVDVPPPEVV HQEP
//