ID D2B7Z8_STRRD Unreviewed; 291 AA.
AC D2B7Z8;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase {ECO:0000313|EMBL:ACZ83929.1};
GN OrderedLocusNames=Sros_0924 {ECO:0000313|EMBL:ACZ83929.1};
OS Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI
OS 9100).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Streptosporangium.
OX NCBI_TaxID=479432 {ECO:0000313|EMBL:ACZ83929.1, ECO:0000313|Proteomes:UP000002029};
RN [1] {ECO:0000313|EMBL:ACZ83929.1, ECO:0000313|Proteomes:UP000002029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100
RC {ECO:0000313|Proteomes:UP000002029};
RX PubMed=21304675; DOI=10.4056/sigs.631049;
RA Nolan M., Sikorski J., Jando M., Lucas S., Lapidus A., Glavina Del Rio T.,
RA Chen F., Tice H., Pitluck S., Cheng J.F., Chertkov O., Sims D., Meincke L.,
RA Brettin T., Han C., Detter J.C., Bruce D., Goodwin L., Land M., Hauser L.,
RA Chang Y.J., Jeffries C.D., Ivanova N., Mavromatis K., Mikhailova N.,
RA Chen A., Palaniappan K., Chain P., Rohde M., Goker M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Streptosporangium roseum type strain (NI
RT 9100).";
RL Stand. Genomic Sci. 2:29-37(2010).
RN [2] {ECO:0007829|PDB:5OCM}
RP X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) IN COMPLEX WITH NADP(+).
RX PubMed=29733377; DOI=10.1093/protein/gzy006;
RA Lenz M., Fademrecht S., Sharma M., Pleiss J., Grogan G., Nestl B.M.;
RT "New imine-reducing enzymes from beta-hydroxyacid dehydrogenases by single
RT amino acid substitutions.";
RL Protein Eng. Des. Sel. 31:109-120(2018).
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; CP001814; ACZ83929.1; -; Genomic_DNA.
DR RefSeq; WP_012887675.1; NC_013595.1.
DR PDB; 5OCM; X-ray; 1.81 A; A/B/C/D/E/F=1-291.
DR PDBsum; 5OCM; -.
DR AlphaFoldDB; D2B7Z8; -.
DR SMR; D2B7Z8; -.
DR STRING; 479432.Sros_0924; -.
DR KEGG; sro:Sros_0924; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_2_1_11; -.
DR OrthoDB; 4535742at2; -.
DR Proteomes; UP000002029; Chromosome.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048666; RedAm-like_C.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR Pfam; PF21761; RedAm-like_C; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5OCM};
KW Nucleotide-binding {ECO:0007829|PDB:5OCM};
KW Reference proteome {ECO:0000313|Proteomes:UP000002029}.
FT DOMAIN 6..160
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 162..287
FT /note="NADPH-dependent reductive aminase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21761"
FT BINDING 11
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:5OCM"
FT BINDING 13
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:5OCM"
FT BINDING 14
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:5OCM"
FT BINDING 33
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:5OCM"
FT BINDING 34
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:5OCM"
FT BINDING 35
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:5OCM"
FT BINDING 68
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:5OCM"
FT BINDING 94
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:5OCM"
FT BINDING 232
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0007829|PDB:5OCM"
SQ SEQUENCE 291 AA; 30017 MW; 4E4962F230D53806 CRC64;
MRDTDVTVLG LGLMGQALAG AFLKDGHATT VWNRSEGKAG QLAEQGAVLA SSARDAAEAS
PLVVVCVSDH AAVRAVLDPL GDVLAGRVLV NLTSGTSEQA RATAEWAAER GITYLDGAIM
AIPQVVGTAD AFLLYSGPEA AYEAHEPTLR SLGAGTTYLG ADHGLSSLYD VALLGIMWGT
LNSFLHGAAL LGTAKVEATT FAPFANRWIE AVTGFVSAYA GQVDQGAYPA LDATIDTHVA
TVDHLIHESE AAGVNTELPR LVRTLADRAL AGGQGGLGYA AMIEQFRSPS A
//
