ID   D2CPI8_HUMAN            Unreviewed;       508 AA.
AC   D2CPI8;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   13-SEP-2023, entry version 50.
DE   SubName: Full=Xeroderma pigmentosum complementation group C protein {ECO:0000313|EMBL:ACE74248.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ACE74248.1};
RN   [1] {ECO:0000313|EMBL:ACE74248.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18685619; DOI=10.1038/jid.2008.239;
RA   Leite R.A., Marchetto M.C., Muotri A.R., Vasconcelos Dde M.,
RA   de Oliveira Z.N., Machado M.C., Menck C.F.;
RT   "Identification of XP complementation groups by recombinant adenovirus
RT   carrying DNA repair genes.";
RL   J. Invest. Dermatol. 129:502-506(2009).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR   EMBL; EU530520; ACE74248.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2CPI8; -.
DR   PeptideAtlas; D2CPI8; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR   Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR   Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR   InterPro; IPR018327; BHD_2.
DR   InterPro; IPR004583; DNA_repair_Rad4.
DR   InterPro; IPR018026; DNA_repair_Rad4-like.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR   InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR   InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR   InterPro; IPR042488; Rad4_BHD3_sf.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   NCBIfam; TIGR00605; rad4; 1.
DR   PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR   PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR   Pfam; PF10403; BHD_1; 1.
DR   Pfam; PF10404; BHD_2; 1.
DR   Pfam; PF10405; BHD_3; 1.
DR   Pfam; PF03835; Rad4; 1.
DR   SMART; SM01030; BHD_1; 1.
DR   SMART; SM01031; BHD_2; 1.
DR   SMART; SM01032; BHD_3; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          300..352
FT                   /note="Rad4 beta-hairpin"
FT                   /evidence="ECO:0000259|SMART:SM01030"
FT   DOMAIN          354..414
FT                   /note="Rad4 beta-hairpin"
FT                   /evidence="ECO:0000259|SMART:SM01031"
FT   DOMAIN          421..495
FT                   /note="Rad4 beta-hairpin"
FT                   /evidence="ECO:0000259|SMART:SM01032"
FT   REGION          1..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACE74248.1"
FT   NON_TER         508
FT                   /evidence="ECO:0000313|EMBL:ACE74248.1"
SQ   SEQUENCE   508 AA;  57207 MW;  AFE2DF3BAE28D5AF CRC64;
     GKKPSKERLT ADPGGSSETS SQVLENHTKP KTSKGTKQEE TFAKGTCRPS AKGKRNKGGR
     KKRSKPSSSE EDEGPGDKQE KATQRRPHGR ERRVASRVSY KEESGSDEAG SGSDFELSSG
     EASDPSDEDS EPGPPKQRKA PAPQRTKAGS KSASRTHRGS HRKDPSLPVA SSSSSSSKRG
     KKMCSDGEKA EKRSIAGIDQ WLEVFCEQEE KWVCVDCVHG VVGQPLTCYK YATKPMTYVV
     GIDSDGWVRD VTQRYDPVWM TVTRKCRVDA EWWAETLRPY QSPFMDREKK EDLEFQAKHM
     DQPLPTAIGL YKNHPLYALK RHLLKYEAIY PETAAILGYC RGEAVYSRDC VHTLHSRDTW
     LKKARVVRLG EVPYKMVKGF SNRARKARLA EPQLREENDL GLFGYWQTEE YQPPVAVDGK
     VPRNEFGNVY LFLPSMMPIG CVQLNLPNLH RVARKLDIDC VQAITGFDFH GGYSHPVTDG
     YIVCEEFKDV LLTAWENEQA VIERKEKE
//