ID D2EIC3_PEDAC Unreviewed; 696 AA.
AC D2EIC3;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:EFA27022.1};
GN ORFNames=HMPREF9024_00593 {ECO:0000313|EMBL:EFA27022.1};
OS Pediococcus acidilactici 7_4.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Pediococcus; Pediococcus acidilactici group.
OX NCBI_TaxID=563194 {ECO:0000313|EMBL:EFA27022.1, ECO:0000313|Proteomes:UP000005738};
RN [1] {ECO:0000313|EMBL:EFA27022.1, ECO:0000313|Proteomes:UP000005738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7_4 {ECO:0000313|EMBL:EFA27022.1,
RC ECO:0000313|Proteomes:UP000005738};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Allen-Vercoe E., Strauss J., Ambrose C., McDonald J., Haas B.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Pediococcus acidilactici strain 7_4.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; GG730084; EFA27022.1; -; Genomic_DNA.
DR RefSeq; WP_002831423.1; NZ_GG730084.1.
DR AlphaFoldDB; D2EIC3; -.
DR HOGENOM; CLU_009289_7_0_9; -.
DR Proteomes; UP000005738; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..297
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 338..665
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 676..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 74959 MW; C290C09A21EEF58A CRC64;
MKNPKKKFRR QKSELPFRLN LIFFGVFALL LLLIGQLGYL QILYGSKLQA EVNRSDNMVE
TENVQRGMIY DSTGKVLVGN KAHQAVSYTK NMNVLPQDMY DVANKLSKYL TVEKNDLTST
DIANYLLADS KNSKAYAQKI PNRENLSSKA LQEKEIAAVK KDHVELTARQ KNAARIYKTI
SGAYQLSTVY IKETDLTSEE LSQIGEHLSE MPGVKITTSW TRNYPAGDDV KSFAGTVSSS
KVGLPSDEVN TLLAEGYARN DRVGQSYLEK RYEPVLKGTK SQTSVEVSSG NQVVKRVQKY
AGKKGDNLVL SINSKFQEEV QKIMKEASQN AGGESTGGYA VVMNPKTGAV IALAGVDRDP
STGKITDNAL GTINEPIVMG SVVKGAMVSG ALMDGVITPK DNTMIDKPIK LAGTGSKSSW
FNSTGSANMP VDVSTALEVS SNSYMMQLAM KEGGFKYKEG AGLAGMNPTV FNKMRGYFEQ
FGLGVKTGID IPGESAGYKG PSSAADIGKA LDLSFGNYDA YTTIQIAQYM STIANGGYRI
APHVVEQIRS SRSNGKLGAV QSTTTPQVLN YIDMSKEEKK MVTDGLYKVV HGTNKYKTGG
PLASISPGIS AKTGTAQTTT NGKSTVTLSL ASFAPSNDPQ VVVALALPGL STSSEADNMN
AAKKIYEAYW KDVQSKSSLE NPTKATKESA AQNLNG
//
