ID D2GV02_AILME Unreviewed; 432 AA.
AC D2GV02; G1LVA8;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Protein ABHD8 {ECO:0000256|ARBA:ARBA00039466};
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 8 {ECO:0000256|ARBA:ARBA00041848};
DE Flags: Fragment;
GN Name=ABHD8 {ECO:0000313|Ensembl:ENSAMEP00000011009.2};
GN ORFNames=PANDA_000514 {ECO:0000313|EMBL:EFB19091.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB19091.1};
RN [1] {ECO:0000313|EMBL:EFB19091.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000011009.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily.
CC {ECO:0000256|ARBA:ARBA00008645}.
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DR EMBL; GL192348; EFB19091.1; -; Genomic_DNA.
DR RefSeq; XP_002912761.1; XM_002912715.3.
DR STRING; 9646.ENSAMEP00000011009; -.
DR ESTHER; ailme-d2gv02; ABHD8.
DR MEROPS; S33.011; -.
DR Ensembl; ENSAMET00000011480.2; ENSAMEP00000011009.2; ENSAMEG00000010469.2.
DR GeneID; 100474429; -.
DR KEGG; aml:100474429; -.
DR CTD; 79575; -.
DR eggNOG; KOG2382; Eukaryota.
DR GeneTree; ENSGT00390000007336; -.
DR HOGENOM; CLU_057347_0_0_1; -.
DR OrthoDB; 3044577at2759; -.
DR TreeFam; TF331708; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR PANTHER; PTHR42886:SF93; PROTEIN ABHD8; 1.
DR PANTHER; PTHR42886; RE40534P-RELATED; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 170..270
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT REGION 47..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 432
FT /evidence="ECO:0000313|EMBL:EFB19091.1"
SQ SEQUENCE 432 AA; 46863 MW; DE2F92C3C9D362C8 CRC64;
MLTGVTDGIF CCLLGAPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG PAPAPNPPPP
PPDAAQGDRS GLVRCQRRIT VYRNGRLLVE NLGRAPRADL LHGQNGSGEP PAALEVELAD
PAGSDGRSGS GSAGSGSGGR RRRARRPKRT IHIDCEKRIT SCKGAQADVV LFFIHGVGGS
LAIWKEQLDF FVRLGYEVVA PDLAGHGASS APQVAAAYTF YALAEDMRAI FKRYAKKRNV
LIGHSYGVSF CTFLAHEYPD LVHKVIMING GGPTALEPSF CSIFNMPTCV LHCLSPCLAW
SFLKAGFARQ GAKEKQLLKE GNAFNVSSFV LRAMMSGQYW PEGDEVYHAE LTVPVLLVHG
MHDKFVPVEE DQRMAEILLL AFLKLIDEGS HMVMLECPET VNTLLHEFLL WEPEPSPKAL
PKPLPAPPEE KK
//
