ID D2GVI6_AILME Unreviewed; 839 AA.
AC D2GVI6;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Heat shock 70 kDa protein 4 {ECO:0000256|ARBA:ARBA00018348};
DE Flags: Fragment;
GN Name=HSPA4 {ECO:0000313|Ensembl:ENSAMEP00000018770.1};
GN ORFNames=PANDA_000741 {ECO:0000313|EMBL:EFB24265.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB24265.1};
RN [1] {ECO:0000313|EMBL:EFB24265.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000018770.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with TJP1/ZO-1. {ECO:0000256|ARBA:ARBA00011800}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|ARBA:ARBA00007381}.
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DR EMBL; GL192350; EFB24265.1; -; Genomic_DNA.
DR RefSeq; XP_002912954.1; XM_002912908.3.
DR STRING; 9646.ENSAMEP00000018770; -.
DR Ensembl; ENSAMET00000019522.2; ENSAMEP00000018770.1; ENSAMEG00000017771.2.
DR GeneID; 100484576; -.
DR KEGG; aml:100484576; -.
DR CTD; 3308; -.
DR eggNOG; KOG0103; Eukaryota.
DR GeneTree; ENSGT00940000156067; -.
DR HOGENOM; CLU_005965_5_1_1; -.
DR OMA; KQIQLYM; -.
DR OrthoDB; 276440at2759; -.
DR TreeFam; TF105043; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR CDD; cd11737; HSPA4_NBD; 1.
DR Gene3D; 1.20.1270.10; -; 2.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR InterPro; IPR042052; HSPA4_NBD.
DR PANTHER; PTHR45639:SF6; HEAT SHOCK 70 KDA PROTEIN 4; 1.
DR PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 2.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT REGION 506..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 839
FT /evidence="ECO:0000313|EMBL:EFB24265.1"
SQ SEQUENCE 839 AA; 94301 MW; B1148E1D240928F0 CRC64;
MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACIS FGPKNRSIGA AAKSQVISNA
KNAVQGFKRF HGRAFSDPFV EAEKCNLAYD IVQLPTGLTG IKVKYMEEER NFTMEQVTAM
LLSKLKETAE SVLKKPVVDC VVSVPCFYTD AERRSVMDAT QIAGLNCLRL MNETTAVALA
YGIYKQDLPA LEEKPRNVVF IDMGHSSYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL
VNHFCEEFGK KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDVDVSGT
MNRGKFLEMC DDLLARVEPP LRSVLEQAKL KKEDIYAVEI VGGATRIPAV KEKISRFFGK
ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY PISLRWNSPA EEGLSDCEVF
TKNHSAPFSK VLTFYRKEPF TLEAYYSSPQ DLPYPDPAIA QFLVQKVTPQ SDGSSSKVKV
KVRVNVHGIF SVSSASLVEV LKFEENEEPM ETDQNAKEEE KMQVDQEEPH AEQQQQTPAE
NKAESEEMET SQAGSKDKKM DQPPQAKKAK VKTSTVDLPI ENQLLWQIDR EMLNLYIENE
GKMIMQDKLE KERNDAKNAV EEYVYEMRDK LSGEYEKFVS EDDRNSFTLK LEDTENWLYE
DGEDQPKQVY VDKLAELKNL GHPIKMRFQE SEERPKLFEE LGKQIQQYMK VISSFKNKED
QYDHLDAADM LKVEKSTNEA MEWMNNRLNL QSKQSLTADP VVKAKEIEAK MKELMSICSP
IISKPKPKVE PPKEEQKNAE QNGPVDGQGD SPGPQAAEQG ADAAVPSESD KKLPEMDID
//
