ID D2GX84_AILME Unreviewed; 1036 AA.
AC D2GX84;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 08-NOV-2023, entry version 72.
DE RecName: Full=RAS p21 protein activator 1 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=PANDA_001485 {ECO:0000313|EMBL:EFB19709.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB19709.1};
RN [1] {ECO:0000313|EMBL:EFB19709.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
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DR EMBL; GL192365; EFB19709.1; -; Genomic_DNA.
DR AlphaFoldDB; D2GX84; -.
DR InParanoid; D2GX84; -.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd08400; C2_Ras_p21A1; 1.
DR CDD; cd13260; PH_RASA1; 1.
DR CDD; cd05391; RasGAP_p120GAP; 1.
DR CDD; cd10354; SH2_Cterm_RasGAP; 1.
DR CDD; cd10353; SH2_Nterm_RasGAP; 1.
DR CDD; cd11788; SH3_RasGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR035842; RasGAP_C_SH2.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR035841; RasGAP_N_SH2.
DR InterPro; IPR035652; RasGAP_SH3.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10194:SF146; RAS GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 170..261
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 268..330
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 340..430
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 463..566
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 566..679
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 737..931
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT NON_TER 1036
FT /evidence="ECO:0000313|EMBL:EFB19709.1"
SQ SEQUENCE 1036 AA; 115217 MW; BED0324FC5B7482C CRC64;
MMAAEAGSEE GGPVTAGAAG GGAAAGSSAY PAVCRVKIPP ALPVAAVPYS GLTEAGVAGT
LAGGAALGSG FLGAGSVAGA MGGAGLSGGG AGAAAAAGPG GEMALAKGTT SLPAETFGAG
GGFPPLPPPP QLPSLGAGLG AVDEGDSLDG PEYEEEEVAI PLTAPPTNQW YHGKLDRTIA
EERLRQAGKS GSYLIRESDR RPGSFVLSFL SQTNVVNHFR IIAMCGDYYI GGRRFSSLSD
LIGYYSHVSC LLKGEKLLYP VAPPEAIEDR RRVRAILPYT KVPDTDEISF LKGDMFIVHN
ELEDGWMWVT NLRTDEQGLI VEDLVEEVGR EEDPHEGKIW FHGKISKQEA YNLLMTVGQV
CSFLVRPSDN TPGDYSLYFR TNENIQRFKI CPTPNNQFMM GGRYYNSIGD IIDHYRKEQI
VEGYYLKEPV PMQDQEQVLN DTVDGKEIYN TIRRKTKDAF YKNIVKKGYL LKKGKGKRWK
NLYFILEGSD AQLIYFESEK RATKPKGLID LSVCSVYVVH DSLFGRPNCF QIVVQHFSEE
HYIFYFAGET PEQAEDWMKG LQAFCSLRKS SPGSSNKRLR QVSSLVLHIE EAHKLPVKHF
TNPYCNIYLN SVQVAKTHAR EGQNPVWSEE FVFDDLPPDI NRFEITLSNK TKKSKDPDIL
FMRCQLSRLQ KGHATDEWFL LSSHIPLKGI EPGSLRVRAR YSMEKIMPEE EYSEFKELVL
QKELHVVYAL SHVCGQDRTL LASILLRIFL HEKLESLLLC TLNDREISME DEATTLFRAT
TLASTLMEQY MKATATQFVH HALKDSILKI MESKQSCELS PSKLEKNEDV NTNLAHLLNI
LSELVEKIFM ASEILPPTLR YIYGCLQKSV QHKWPTNTTM RTRVVSGFVF LRLICPAILN
PRMFNIISDS PSPIAARTLI LVAKSVQNLA NLVEFGAKEP YMEGVNPFIK SNKHRMIMFL
DELGNVPELP DTTEHSRTDL SRDLAALHEI CVAHSDELRT LSNERGAQQH VLKKLLAITE
LLQQKQNQYT KTNDVR
//
