ID D2H095_AILME Unreviewed; 1192 AA.
AC D2H095;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=DNA repair protein complementing XP-G cells {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=PANDA_002828 {ECO:0000313|EMBL:EFB25962.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB25962.1};
RN [1] {ECO:0000313|EMBL:EFB25962.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
CC {ECO:0000256|ARBA:ARBA00005283}.
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DR EMBL; GL192404; EFB25962.1; -; Genomic_DNA.
DR AlphaFoldDB; D2H095; -.
DR InParanoid; D2H095; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd09904; H3TH_XPG; 1.
DR CDD; cd09868; PIN_XPG_RAD2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR NCBIfam; TIGR00600; rad2; 1.
DR PANTHER; PTHR16171:SF7; DNA EXCISION REPAIR PROTEIN ERCC-5; 1.
DR PANTHER; PTHR16171; DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00841; XPG_1; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 1..98
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 785..854
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 146..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1088
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1192
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1192
FT /evidence="ECO:0000313|EMBL:EFB25962.1"
SQ SEQUENCE 1192 AA; 132634 MW; 45179E77BBCC00EA CRC64;
MGVHGLWKLL ECSGRQVNPE TLEGKILAVD ISIWLNQALR GVRDCHGNSI ENAHLLTLFH
RLCKLLFFRI RPIFVFDGDA PLLKKQTLAK RRHRKDLATT DSRKTTEKLL KTFLKRQAIK
TALKSKRQDE DLPSLTQVQR EDDIYVLPPL QKEEKNSSEE EDEREWQERM SQKQALQEEF
FHNPHAIDIE SEDFSSLPLE IKHEILTDMK EFTKRRRTLF EAMPEESNDF SQYQLKGLLK
KNLLNQHIEN VQKEMNQQQS GQIQRQYEDE GGFLKEVESR RVVSEDTSHY ILIRGIQAKK
VAEVGSEALP SSSDMHSRSF DTKSSPCENL KPEKEAAAAP PSPRTSLAVQ AAMRGSSSEE
EWESENQKQS DVKNAPVSPR TLLAIQKVLD DDEDMEAHAG NDAQTGGSGV ETLVENSCHE
EAAEGLEEGD GEGMLLPAGP HLTRVDCAHE PSPDSSRRLA DSALLSRPVF CPGSESSVPK
EEMSLTHVVS EAFQTSDESS VKGGKDPVPP ESTVVMRSDA PGPQGGRQLT PGPPVSLSSV
PRNETHTKEP GLQPDLCPSG SKCDSSVLSS DDETECEKNP VSEIVATVSL QEMSNTQNVP
SEAISNLENA GSFHSEEHDN FLKTIQEHET VVSADQDLIS VLKSVEPVEM DSEESESDGS
FIEVQSIISN DELQAELHEA SESPSRQDEE EPIGTRKEEA TGDSEGLLTH DSGSEALDTE
PHEEAEKDAD SSLNEWQDIN LEELETLENS LLAQQNSLKA QKQQQERIAA TVTGQMFLES
QELLRLFGIP YIEAPMEAEA QCAILDLTDQ TSGTITDDSD IWLFGARHVY KNFFNKNKFV
EYYQYVDFHN QLGLDRNKLI NLAYLLGSDY TEGIPTVGCV TAMEILNEFP GHGLEPLLKF
SEWWHEAQKN KKIRPNPYDT KVKKKLRKLQ LTPGFPNPAV ADAYLKPVVD DSRGSFLWGK
PDLDKIREFC QRYFGWNRTK TDESLFPVLK QLNAQQTQLR IDSFFRLAQQ ERQDAKGIRS
QRLNRAVTCM LRKEREAAAS EIEAMSVAME NDFEFPDKAK GKTQKRSIAN KWEESSSLKR
KRLSDSKQES KCGGFLGGAC PSPSSGTSSG EDAECVSSVN VQRGRAAPES PASRPGLQSA
ASPAPARDQG ATTSSSSDDD GGGPAPVLVT ARSVFGRRKG KGRGTRGRKR KS
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