ID D2H1P6_AILME Unreviewed; 392 AA.
AC D2H1P6;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Cytochrome P450 {ECO:0000256|RuleBase:RU368047};
DE EC=1.14.14.- {ECO:0000256|RuleBase:RU368047};
DE Flags: Fragment;
GN ORFNames=PANDA_003469 {ECO:0000313|EMBL:EFB15239.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB15239.1};
RN [1] {ECO:0000313|EMBL:EFB15239.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC In liver microsomes, this enzyme is involved in an NADPH-dependent
CC electron transport pathway. It oxidizes a variety of structurally
CC unrelated compounds, including steroids, fatty acids, and xenobiotics.
CC {ECO:0000256|RuleBase:RU368047}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|RuleBase:RU368047};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368047}. Microsome membrane
CC {ECO:0000256|RuleBase:RU368047}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU368047}.
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DR EMBL; GL192431; EFB15239.1; -; Genomic_DNA.
DR AlphaFoldDB; D2H1P6; -.
DR InParanoid; D2H1P6; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF378; CYTOCHROME P450; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR01686; EP450ICYP2D.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Heme {ECO:0000256|RuleBase:RU368047}; Iron {ECO:0000256|RuleBase:RU368047};
KW Metal-binding {ECO:0000256|RuleBase:RU368047};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Monooxygenase {ECO:0000256|RuleBase:RU368047};
KW Oxidoreductase {ECO:0000256|RuleBase:RU368047}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB15239.1"
FT NON_TER 392
FT /evidence="ECO:0000313|EMBL:EFB15239.1"
SQ SEQUENCE 392 AA; 44991 MW; CDBC26D6CA37D1F7 CRC64;
KLSQKYGSIY SIQMGPKKVV VLSGYETVKD ALVSYGDQFG ERSQVPIFER LFEGKGIVFS
HGETWRTMRR FSLTTLRNFG MGKRLIEDTI IEECQHLVRS FESHRGKPFE VTTVMNASVA
NVIVSVLLGK RFDYQDTQFL RLLTLIGENV KLVGSPRIAL FNMFPVLGFL LKSHKTVLKN
RDELFAFIRM TFLDHQHKFD KNDPRSLIDA FLVRQQEEKR TSTAYFSDEN LVALVSNLFA
AGTETTASTL RWALLLMMRY PEVQKKVCDE ITKVVGSAQP RIAHRTQMPY TDAVIHEVQR
FANILPTSLP HATTTDVMFK NYYIPKGTEV ITLLTSVLRD QTQWEKPDTF NPEHFLSSTG
KFIKKEAFMP FSLGKVFYFE TGGLKNLERF AF
//
