ID D2H326_AILME Unreviewed; 769 AA.
AC D2H326;
DT 09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT 09-FEB-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=HP domain-containing protein {ECO:0000259|PROSITE:PS51089};
DE Flags: Fragment;
GN ORFNames=PANDA_004141 {ECO:0000313|EMBL:EFB28896.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB28896.1};
RN [1] {ECO:0000313|EMBL:EFB28896.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
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DR EMBL; GL192457; EFB28896.1; -; Genomic_DNA.
DR AlphaFoldDB; D2H326; -.
DR HOGENOM; CLU_002568_3_1_1; -.
DR InParanoid; D2H326; -.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd11289; gelsolin_S2_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11293; gelsolin_S4_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.40.20.10; Severin; 6.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977:SF33; ADVILLIN; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 6.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 4.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 2.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203}.
FT DOMAIN 703..769
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFB28896.1"
FT NON_TER 769
FT /evidence="ECO:0000313|EMBL:EFB28896.1"
SQ SEQUENCE 769 AA; 86256 MW; 3F8AC07E056A13F1 CRC64;
TRRAGSLLSQ DIHFWIGKDS SQDEQTCAAV YTTQLDDYLG GSPVQHREVQ YHESDTFHGY
FKQGIIYKKG GVASGMKHVE TNTYDVKRLL HVKGKRNIRA TEVEMSWDSF NQGDVFLLDL
GKVIIQWNGP ESNSGERLKA MLLAKDIRDR ERGGRAEIGV IEGDKEAASP ELMKVLQDTL
GRRSVIKPAV PDEIIDQQQK SNIMLYHVSD SAGQLAITEV ATRPLVQDLL NHDDCYILDQ
SGTKIYVWKG RGATKIEKQT AMSKALNFIQ MKGYPSSTNV ETINDGAESA MFKQLFQKWS
VKDQTVGLGK TFGVGKIAKV LQDKFDVTLL HTRPEVAAQE RMVDDGTGAV EVWRIENLEL
VPVEHEWYGF FYGGDCYLVL YTYEVTGRPH HVLYIWQGRH ASKDELAASA YQAVEVGRQF
GGAAVQVRVT MGKEPRHFMA IFKGKLVIFE GGTSRKGNAE PDPPVRLFQI QGNDKSNTKA
VEVPALASSL NSNDVFLLRT QAAHYLWYGK GSSGDERAMA KELASLLCEG TEDAVAEGQE
PAEFWDLLGG KTAYADHKRL QQEILDVQPR LFECSNKIGR FVVTEITDFT QDDLNPGDVM
LLDTWDQVFL WIGAEAKATE KESALEMARE YLSTHPGGRD TGTPTLIIKQ GFEPPVFTGW
FLAWDPHIWS ARKSYEQLKE ELGDAAAITR ITADMRNATL TLNSEPKYYP IEVLLKNQNQ
ELPEDVNPAK KENYLSEQDF ISVFGITRGQ FAALPGWKQL QMKKEKGLF
//
